TY - JOUR
T1 - Self-reported adherence to antiretroviral medications among participants in HIV clinical trials
T2 - The AACTG Adherence Instruments
AU - Chesney, Margaret A.
AU - Ickovics, J. R.
AU - Chambers, D. B.
AU - Gifford, A. L.
AU - Neidig, J.
AU - Zwickl, B.
AU - Wu, A. W.
N1 - Funding Information:
The auhorts wish to acknowledge the insight and leadership of Samuel Bozzette in establishing effots torstuy hedalth outcomes and illness behvais witohinuthe rAACTG. The auhorts would like to thank Susan A. Kelly, Coordinator of the AACTG Operations Center, William Wilson of the AACTG Cmuonity mCotintnuysGcroupe, and Katrina Thaos admnMark Shiner of the Center for AIDS Peventiron Studies, UCSF, for their inlaubve alasistsae nc inprepraanotthifsomi cripta.nTheuausatohlacsknoloreewtdheegraxotyrcod-ninar tributions of the resechaproelnrasdnnstdueypaipantrs ateitchaoctfehpaiptinrg taic AIDSClinicalTrsiUantl(AiTUC)sites:UnersiityvoCf a,SlaniDfog;Uirneneriiysivta ofCaloirfn,SniFaancrcoi;asUnersiityvoCfinintci;UnneariiysvtoHf ;aHwardoawii Unersiityv;InaUdneiriiasv;tOnyoStatheUiniityv;UneerriiysvstoRof scter;hSanfetdor Unersiityv; and Washington Unersiityv. Support was reiveedcfrom the following sources: Chesney and Chmbersa: Social and ScientiŽ c Systems cooperative aeemgenrt wh NitDI#A01UAI8I; 53N88HI#M0P5 MH42459; NIAID #30 MH5P9037 UCSF-GIVI Center for AIDS Researh;cUCSF California AIDS ResechaCenterr. Icko:vAmFAicR Scsholar Award and NIDA #1R01 DA08143– 01. Giffod: Drepartment of Veteran Affairs and NINR #5 R01 NR04415. Neidig: NIAID #AI25924 (R.J. Fss).aZwkl: iNcIDI#A01UA5I.2W9:5Nu8DI#UA01AI 681. 276 Supported in part by the Adult AIDS Clinical Tials Grroup of the National Institute of Allergy and Infectious Diseases. The AACTG Cooeptivre aaeegenmrt GrntaNUOo1 AI38858. Supported in part bthye General Clinical Researh cCenter Units funded by the National Center for Researh cResources.
Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2000
Y1 - 2000
N2 - This paper describes the AACTG Adherence Instruments, which are comprised a two self-report questionnaires for use in clinical trials conducted by the Adult AIDS Clinical Trials Group (AACTG). The questionnaires were administered to 75 patients at ten AACTG sites in the USA. All patients were taking combination antiretroviral therapy (ART), including at least one protease inhibitor. Eleven per cent of patients reported missing at least one dose the day before the interview, and 17% reported missing at least one dose during the two days prior. The most common reasons for missing medications included 'simply forgot' (66%) and a number of factors often associated with improved health, including being busy (53%), away from home (57%) and changes in routine (51%). Less adherent patients reported lower adherence self-efficacy (p = 0. 006) and were less sure of the link between non-adherence and the development of drug resistance (p = 0.009). They were also more likely to consume alcohol, to be employed outside the home for pay and to have enrolled in clinical trials to gain access to drugs (all p < 005). Twenty-two per cent of patients taking drugs requiring special instructions were unaware of these instructions. Each questionnaire took approximately ten minutes to complete. Responses to the questionnaires were favourable. These questionnaires have been included in six AACTG clinical trials to date and have been widely disseminated to investigators both in the USA and abroad.
AB - This paper describes the AACTG Adherence Instruments, which are comprised a two self-report questionnaires for use in clinical trials conducted by the Adult AIDS Clinical Trials Group (AACTG). The questionnaires were administered to 75 patients at ten AACTG sites in the USA. All patients were taking combination antiretroviral therapy (ART), including at least one protease inhibitor. Eleven per cent of patients reported missing at least one dose the day before the interview, and 17% reported missing at least one dose during the two days prior. The most common reasons for missing medications included 'simply forgot' (66%) and a number of factors often associated with improved health, including being busy (53%), away from home (57%) and changes in routine (51%). Less adherent patients reported lower adherence self-efficacy (p = 0. 006) and were less sure of the link between non-adherence and the development of drug resistance (p = 0.009). They were also more likely to consume alcohol, to be employed outside the home for pay and to have enrolled in clinical trials to gain access to drugs (all p < 005). Twenty-two per cent of patients taking drugs requiring special instructions were unaware of these instructions. Each questionnaire took approximately ten minutes to complete. Responses to the questionnaires were favourable. These questionnaires have been included in six AACTG clinical trials to date and have been widely disseminated to investigators both in the USA and abroad.
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U2 - 10.1080/09540120050042891
DO - 10.1080/09540120050042891
M3 - Article
C2 - 10928201
AN - SCOPUS:0001696152
SN - 0954-0121
VL - 12
SP - 255
EP - 266
JO - AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV
JF - AIDS Care - Psychological and Socio-Medical Aspects of AIDS/HIV
IS - 3
ER -