Abstract
Introduction: A long-term peripheral neural interface is an area of intense research. The use of electrode interfaces is limited by the biological response to the electrode material. Methods: We created an electrode construct to harbor the rat sciatic nerve with interposition of autogenous adipose tissue between the nerve and the electrode. The construct was implanted for 10 weeks. Results: Immunohistochemistry showed a unique laminar pattern of axonal growth layered between fibro-collagenous tissue, forming a physical interface with the tungsten micro-electrode. Action potentials transmitted across the intrerface showed mean conduction velocities varying between 6.99±2.46 and 20.14±4 m/s. Conclusions: We have demonstrated the feasibility of a novel peripheral nerve interface through modulation of normal biologic phenomena. It has potential applications as a chronic implantable neural interface.
Original language | English (US) |
---|---|
Pages (from-to) | 789-796 |
Number of pages | 8 |
Journal | Muscle and Nerve |
Volume | 53 |
Issue number | 5 |
DOIs | |
State | Published - May 1 2016 |
Externally published | Yes |
Keywords
- Bionic
- Injury
- Interface
- Nerve
- Prosthesis
ASJC Scopus subject areas
- Physiology
- Clinical Neurology
- Cellular and Molecular Neuroscience
- Physiology (medical)