Self-organization of "fibro-axonal" composite tissue around unmodified metallic micro-electrodes can form a functioning interface with a peripheral nerve

A new direction for creating long-term neural interfaces

Amitabha Lahiri, Ignacio Martinez Delgado, Swathi Sheshadri, Kian Ann Ng, Sudip Nag, Shih Cheng Yen, Nitish V Thakor

Research output: Contribution to journalArticle

Abstract

Introduction: A long-term peripheral neural interface is an area of intense research. The use of electrode interfaces is limited by the biological response to the electrode material. Methods: We created an electrode construct to harbor the rat sciatic nerve with interposition of autogenous adipose tissue between the nerve and the electrode. The construct was implanted for 10 weeks. Results: Immunohistochemistry showed a unique laminar pattern of axonal growth layered between fibro-collagenous tissue, forming a physical interface with the tungsten micro-electrode. Action potentials transmitted across the intrerface showed mean conduction velocities varying between 6.99±2.46 and 20.14±4 m/s. Conclusions: We have demonstrated the feasibility of a novel peripheral nerve interface through modulation of normal biologic phenomena. It has potential applications as a chronic implantable neural interface.

Original languageEnglish (US)
JournalMuscle and Nerve
DOIs
StateAccepted/In press - 2016
Externally publishedYes

Fingerprint

Peripheral Nerves
Electrodes
Biological Phenomena
Tungsten
Sciatic Nerve
Action Potentials
Adipose Tissue
Immunohistochemistry
Direction compound
Growth
Research

Keywords

  • Bionic
  • Injury
  • Interface
  • Nerve
  • Prosthesis

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)
  • Physiology

Cite this

Self-organization of "fibro-axonal" composite tissue around unmodified metallic micro-electrodes can form a functioning interface with a peripheral nerve : A new direction for creating long-term neural interfaces. / Lahiri, Amitabha; Delgado, Ignacio Martinez; Sheshadri, Swathi; Ng, Kian Ann; Nag, Sudip; Yen, Shih Cheng; Thakor, Nitish V.

In: Muscle and Nerve, 2016.

Research output: Contribution to journalArticle

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AU - Delgado, Ignacio Martinez

AU - Sheshadri, Swathi

AU - Ng, Kian Ann

AU - Nag, Sudip

AU - Yen, Shih Cheng

AU - Thakor, Nitish V

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