Self-ordered pointing performance in Huntington's disease patients

Jill B. Rich, Frederick W. Bylsma, Jason Brandt

Research output: Contribution to journalArticlepeer-review

Abstract

The ability to organize, perform, monitor, and remember sequences of movements is typically ascribed to the frontal cortex. In this study, 13 Huntington's disease (HD) patients and 13 healthy control subjects (NC) were examined on a modified version of the Petrides and Milner self-ordered pointing task. HD patients made more errors in every task condition relative to NC subjects. However, task manipulations, including variations in list length, verbal versus nonverbal materials, and concrete versus abstract stimuli, affected HD patients in the same way as they did the NC subjects. Among the patients, disease severity correlated with performance in the most difficult condition only. The HD patients' impaired performance on this task is most likely attributable to disruption of frontal-subcortical circuits stemming from striatal neuronal loss.

Original languageEnglish (US)
Pages (from-to)99-106
Number of pages8
JournalNeuropsychiatry, Neuropsychology and Behavioral Neurology
Volume9
Issue number2
StatePublished - Apr 1 1996

Keywords

  • Huntington's disease
  • Memory
  • Sequencing

ASJC Scopus subject areas

  • Psychology(all)
  • Neurology
  • Clinical Neurology
  • Psychiatry and Mental health

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