Self-injection of barbiturates and benzodiazepines in baboons

Roland R Griffiths, Scott E. Lukas, L. DiAnne Bradford, Joseph V. Brady, Jack D. Snell

Research output: Contribution to journalArticle

Abstract

Self-injection of three barbiturates, six benzodiazepines, and chlorpromazine was examined in baboons. Intravenous injections of drug were dependent upon completion of 160 lever presses (a 160-response fixed-ratio schedule). A 3-h time-out period followed each injection, permitting a maximum of eight injections per day. Prior to testing each dose of drug, self-injection performance was established with cocaine. Subsequently, a test dose was substituted for cocaine. Amobarbital, pentobarbital, and secobarbital maintained the highest levels of self-injection, which were similar to those maintained by cocaine. Clonazepam, clorazepate, diazepam, flurazepam, medazepam, and midazolam maintained relatively modest levels of self-injection, while chlorpromazine maintained only low levels, which were in the range of vehicle control. Of the six benzodiazepines, midazolam produced the highest levels of self-injection. At the highest self-injected doses, the barbiturates produced anesthesia in contrast to the benzodiazepines, which produced only sedation. None of the drugs affected food intake except for chlorpromazine, which produced dose-related decreases. The differences among the drug classes (i.e., barbiturate, benzodiazepine, phenothiazine) with respect to the maintenance of self-injection correspond well with the results of previous animal and human drug self-administration studies.

Original languageEnglish (US)
Pages (from-to)101-109
Number of pages9
JournalPsychopharmacology
Volume75
Issue number2
DOIs
StatePublished - Nov 1981

Fingerprint

Barbiturates
Papio
Benzodiazepines
Injections
Chlorpromazine
Cocaine
Pharmaceutical Preparations
Midazolam
Medazepam
Secobarbital
Flurazepam
Amobarbital
Clonazepam
Self Administration
Pentobarbital
Diazepam
Intravenous Injections
Appointments and Schedules
Anesthesia
Eating

Keywords

  • Amobarbital
  • Baboons
  • Chlorpromazine
  • Clonazepam
  • Clorazepate
  • Cocaine
  • Diazepam
  • Drug self-administration
  • Flurazepam
  • Medazepam
  • Midazolam
  • Pentobarbital
  • Secobarbital

ASJC Scopus subject areas

  • Pharmacology

Cite this

Griffiths, R. R., Lukas, S. E., Bradford, L. D., Brady, J. V., & Snell, J. D. (1981). Self-injection of barbiturates and benzodiazepines in baboons. Psychopharmacology, 75(2), 101-109. https://doi.org/10.1007/BF00432169

Self-injection of barbiturates and benzodiazepines in baboons. / Griffiths, Roland R; Lukas, Scott E.; Bradford, L. DiAnne; Brady, Joseph V.; Snell, Jack D.

In: Psychopharmacology, Vol. 75, No. 2, 11.1981, p. 101-109.

Research output: Contribution to journalArticle

Griffiths, RR, Lukas, SE, Bradford, LD, Brady, JV & Snell, JD 1981, 'Self-injection of barbiturates and benzodiazepines in baboons', Psychopharmacology, vol. 75, no. 2, pp. 101-109. https://doi.org/10.1007/BF00432169
Griffiths, Roland R ; Lukas, Scott E. ; Bradford, L. DiAnne ; Brady, Joseph V. ; Snell, Jack D. / Self-injection of barbiturates and benzodiazepines in baboons. In: Psychopharmacology. 1981 ; Vol. 75, No. 2. pp. 101-109.
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