Self-expandable and highly flexible nitinol stent: Immediate and long-term results in dogs

Ehud Grenadier, Rona Shofti, Mordechai Beyar, Haim Lichtig, Daniel Mordechowitz, Oren Globerman, Walter Markiewicz, Rafael Beyar

Research output: Contribution to journalArticle

Abstract

We sought to investigate the acute and long-term patency rates and the histologic response of coronary arteries to a self-expandable nitinol coil stent. Twenty-two stents were implanted. Angiographic patency was demonstrated acutely in all but one dog, in which the stent was released in a small branch (1 mm); mismatch in stent-to-artery diameters resulted in vessel closure. Two dogs died from anesthesia overdose and two from bleeding within 24 hours. All dogs were treated with aspirin (80 mg/day) and warfarin (2.5 mg/day) for up to 1 month. Sixteen dogs were monitored for 1 to 2 weeks, 1 month, 3 months, 6 months, and 1 year and underwent subsequent angiography and histopathologic examination. Angiographic artery dimensions measured immediately after stent implantation (2.72 ± 0.4 mm) did not differ from those noted at follow-up (2.68 ± 0.44 mm, p not significant). Histologic examination showed outward stent pressure compressing the internal elastic membrane and media in most cases. Intimal hyperplasia started at 2 weeks and was most apparent at 3 and 6 months. Mean intimal thickness was 30.7 ± 10.9μ, 141.8 ± 105.4μ, 227.1 ± 104.1μ, 211.8 ± 99.1μ, and 170.1 ± 42.7μ at 1 to 2 weeks and 1, 3, 6 and 12 months, respectively. Therefore the nitinol self-expandable stent provokes a moderate cellular proliferative response that reaches its maximum in 3 to 6 months without further progression.

Original languageEnglish (US)
Pages (from-to)870-878
Number of pages9
JournalAmerican Heart Journal
Volume128
Issue number5
DOIs
StatePublished - 1994
Externally publishedYes

Fingerprint

Stents
Dogs
Tunica Intima
Arteries
Warfarin
nitinol
Aspirin
Hyperplasia
Coronary Vessels
Angiography
Anesthesia
Hemorrhage
Pressure
Membranes

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Grenadier, E., Shofti, R., Beyar, M., Lichtig, H., Mordechowitz, D., Globerman, O., ... Beyar, R. (1994). Self-expandable and highly flexible nitinol stent: Immediate and long-term results in dogs. American Heart Journal, 128(5), 870-878. https://doi.org/10.1016/0002-8703(94)90582-7

Self-expandable and highly flexible nitinol stent : Immediate and long-term results in dogs. / Grenadier, Ehud; Shofti, Rona; Beyar, Mordechai; Lichtig, Haim; Mordechowitz, Daniel; Globerman, Oren; Markiewicz, Walter; Beyar, Rafael.

In: American Heart Journal, Vol. 128, No. 5, 1994, p. 870-878.

Research output: Contribution to journalArticle

Grenadier, E, Shofti, R, Beyar, M, Lichtig, H, Mordechowitz, D, Globerman, O, Markiewicz, W & Beyar, R 1994, 'Self-expandable and highly flexible nitinol stent: Immediate and long-term results in dogs', American Heart Journal, vol. 128, no. 5, pp. 870-878. https://doi.org/10.1016/0002-8703(94)90582-7
Grenadier, Ehud ; Shofti, Rona ; Beyar, Mordechai ; Lichtig, Haim ; Mordechowitz, Daniel ; Globerman, Oren ; Markiewicz, Walter ; Beyar, Rafael. / Self-expandable and highly flexible nitinol stent : Immediate and long-term results in dogs. In: American Heart Journal. 1994 ; Vol. 128, No. 5. pp. 870-878.
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