Self-administered multi-level pregnancy tests in simplified follow-up of medical abortion in Tunisia

Rasha Dabash, Tara Shochet, Selma Hajri, Héla Chelli, Anne Emmanuele Hassairi, Douha Haleb, Hayet Labassi, Ezzedine Sfar, Fatma Temimi, Leah Koenig, Beverly Winikoff

Research output: Contribution to journalArticle

Abstract

Background: This study was conducted to assess the efficacy and acceptability of using a multi-level pregnancy test (MLPT) combined with telephone follow-up for medical abortion in Tunisia, where the majority of providers are midwives. Methods: Four hundred and four women with gestational age ≤ 70 days' LMP seeking medical abortion at six study sites were enrolled in this open-label trial. Participants administered a baseline MLPT at the clinic prior to mifepristone administration and were asked to take a second MLPT at home and to call in its results before returning the day of their scheduled follow-up visit 10-14 days later. Results: Almost all women with follow-up (97.1 %, n = 332/342) had successful abortions without the need for surgical intervention. The MLPT worked extremely well among women ≤63 days' LMP in ruling out ongoing pregnancy (negative predictive value (NPV) =100 % (n = 298/298)) and also detecting women with ongoing pregnancies (sensitivity = 100 %; 2/2) as needing follow-up due to non-declining hCG. Among women 64-70 days' LMP, the test also worked well in ruling out ongoing pregnancy (NPV = 96.9 % (n = 31/32) but not as well in terms of sensitivity (50 %), with only one of two ongoing pregnancies detected by MLPT as needing follow-up. Most women (95.1 %) found the MLPT to be very easy or easy to use and would consider using the MLPT again (97.4 %) if needed. Conclusions: Self-administered pre and post MLPT are very easy for women to use and accurate in assessing medical abortion success up to 63 days' LMP. MLPT use for medical abortion follow-up has the potential to facilitate task sharing services and eliminate the burden of routine in-person follow-up visits for the large majority of women. Additional research is warranted to explore the accuracy of the MLPT in identifying ongoing pregnancy among women with gestational ages > 63 days. Trial registration: This study was registered on May 13, 2010, on clinicaltrials.gov as NCT01150279.

Original languageEnglish (US)
Article number49
JournalBMC Women's Health
Volume16
Issue number1
DOIs
StatePublished - Jul 30 2016
Externally publishedYes

Keywords

  • Medical abortion
  • Multi-level pregnancy test
  • Semi-quantitative pregnancy test
  • Tunisia

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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  • Cite this

    Dabash, R., Shochet, T., Hajri, S., Chelli, H., Hassairi, A. E., Haleb, D., Labassi, H., Sfar, E., Temimi, F., Koenig, L., & Winikoff, B. (2016). Self-administered multi-level pregnancy tests in simplified follow-up of medical abortion in Tunisia. BMC Women's Health, 16(1), [49]. https://doi.org/10.1186/s12905-016-0327-1