Selenium status and blood lipids: The cardiovascular risk in young finns study

S. Stranges, A. G. Tabák, Eliseo Guallar, M. P. Rayman, T. N. Akbaraly, M. Laclaustra, G. Alfthan, H. Mussalo-Rauhamaa, J. S A Viikari, O. T. Raitakari, M. Kivimäki

Research output: Contribution to journalArticle

Abstract

Background. Concern has been recently raised about possible adverse cardio-metabolic effects of high selenium status, such as increased risks of diabetes and hyperlipidaemia. However, most of the evidence comes from selenium-replete populations such as that of the United States. Objectives. To examine cross-sectional and longitudinal associations of serum selenium with cardiovascular risk factors in Finland where selenium levels were amongst the lowest in the world until the early 1980s before the implementation of a nationwide selenium fertilization programme. Methods. Serum selenium was measured in 1235 young Finns aged 3-18years at baseline in 1980 (prefertilization) and in a subgroup (N=262) at the 6-year follow-up (1986, postfertilization). During the 27-year follow-up, serum lipids, blood pressure, body mass index and smoking were assessed five times (1980, 1983, 1986, 2001 and 2007). Results. Mean (±SD) serum selenium concentrations were 74.3±14.0ngmL -1 in 1980 and 106.6±12.5ngmL -1 in 1986 (average increase 32.3ngmL -1; 95% CI: 30.3 to 34.3, P-1 (95% CI: -0.30 to -0.10, P-1 (95% CI: 0.03 to 0.10, P-1 (95% CI: -0.31 to -0.14, P

Original languageEnglish (US)
Pages (from-to)469-477
Number of pages9
JournalJournal of Internal Medicine
Volume270
Issue number5
DOIs
StatePublished - Nov 2011

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Selenium
Lipids
Serum
Finland
Hyperlipidemias
Fertilization
Body Mass Index
Smoking
Blood Pressure
Population

Keywords

  • Cardiovascular
  • Cross-sectional
  • Follow-up
  • Lipids
  • Risk factors
  • Selenium

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Stranges, S., Tabák, A. G., Guallar, E., Rayman, M. P., Akbaraly, T. N., Laclaustra, M., ... Kivimäki, M. (2011). Selenium status and blood lipids: The cardiovascular risk in young finns study. Journal of Internal Medicine, 270(5), 469-477. https://doi.org/10.1111/j.1365-2796.2011.02398.x

Selenium status and blood lipids : The cardiovascular risk in young finns study. / Stranges, S.; Tabák, A. G.; Guallar, Eliseo; Rayman, M. P.; Akbaraly, T. N.; Laclaustra, M.; Alfthan, G.; Mussalo-Rauhamaa, H.; Viikari, J. S A; Raitakari, O. T.; Kivimäki, M.

In: Journal of Internal Medicine, Vol. 270, No. 5, 11.2011, p. 469-477.

Research output: Contribution to journalArticle

Stranges, S, Tabák, AG, Guallar, E, Rayman, MP, Akbaraly, TN, Laclaustra, M, Alfthan, G, Mussalo-Rauhamaa, H, Viikari, JSA, Raitakari, OT & Kivimäki, M 2011, 'Selenium status and blood lipids: The cardiovascular risk in young finns study', Journal of Internal Medicine, vol. 270, no. 5, pp. 469-477. https://doi.org/10.1111/j.1365-2796.2011.02398.x
Stranges, S. ; Tabák, A. G. ; Guallar, Eliseo ; Rayman, M. P. ; Akbaraly, T. N. ; Laclaustra, M. ; Alfthan, G. ; Mussalo-Rauhamaa, H. ; Viikari, J. S A ; Raitakari, O. T. ; Kivimäki, M. / Selenium status and blood lipids : The cardiovascular risk in young finns study. In: Journal of Internal Medicine. 2011 ; Vol. 270, No. 5. pp. 469-477.
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AU - Laclaustra, M.

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