Selenium and maternal blood pressure during childbirth

Ellen M. Wells, Lynn R. Goldman, Jeffery M. Jarrett, Benjamin J. Apelberg, Julie B. Herbstman, Kathleen L. Caldwell, Rolf U. Halden, Frank R. Witter

Research output: Contribution to journalArticle

Abstract

Evidence suggests selenium concentrations outside the nutritional range may worsen cardiovascular health. This paper examines the relationship between selenium and maternal blood pressure (BP) among 270 deliveries using umbilical cord serum as a proxy for maternal exposure levels. Multivariable models used linear splines for selenium and controlled for gestational age, maternal age, race, median household income, parity, smoking, and prepregnancy body mass index. Non-parametric analysis of this dataset was used to select spline knots for selenium at 70 and 90 g/l. When selenium was 70 g/l, increasing selenium levels were related to a non-statistically significant decrease in BP. For selenium 70-90 g/l, a 1 g/l increase was related to a 0.37 mm Hg (95% confidence interval (CI): 0.005, 0.73) change in systolic and a 0.35 mm Hg (0.07, 0.64) change in diastolic BP. There were very few selenium values 90 g/l. Other studies indicate that the maternal/cord selenium ratio is 1.46 (95% CI: 1.28, 1.65). This u-shaped relationship between selenium and BP is consistent with a dual role of selenium as an essential micronutrient that is nonetheless a toxicant at higher concentrations; however, this needs to be studied further.

Original languageEnglish (US)
Pages (from-to)191-197
Number of pages7
JournalJournal of Exposure Science and Environmental Epidemiology
Volume22
Issue number2
DOIs
StatePublished - Mar 1 2012

Keywords

  • blood pressure
  • pregnancy
  • selenium
  • umbilical cord

ASJC Scopus subject areas

  • Epidemiology
  • Toxicology
  • Pollution
  • Public Health, Environmental and Occupational Health

Fingerprint Dive into the research topics of 'Selenium and maternal blood pressure during childbirth'. Together they form a unique fingerprint.

  • Cite this

    Wells, E. M., Goldman, L. R., Jarrett, J. M., Apelberg, B. J., Herbstman, J. B., Caldwell, K. L., Halden, R. U., & Witter, F. R. (2012). Selenium and maternal blood pressure during childbirth. Journal of Exposure Science and Environmental Epidemiology, 22(2), 191-197. https://doi.org/10.1038/jes.2011.42