Selectivity of mediators released by eosinophils

Monique Capron, Margherita Tomassini, Gérard Torpier, Jean Pierre Kusnierz, Susan M MacDonald, André Capron

Research output: Contribution to journalArticle

Abstract

The presence of receptors for IgE on eosinophils has drawn the attention on their direct participation in IgE-dependent hypersensitivity reactions. Surface IgE antibodies were detected on eosinophils from allergic patients. The addition of the specific allergen or anti-IgE antibodies to such purified eosinophils induced the release of eosinophil peroxidase, but not of eosinophil cationic protein. These findings associated with results obtained by using electron microscopy and immunogold staining of the various antibodies directed against the granule proteins allowed us to suggest a selectivity in the mediators released by eosinophils. In addition, preliminary results concerning the existence and the functional role of a receptor for IgA on eosinophils are reported, leading to the concept of a particular interaction of eosinophils with immunoglobulins present in the tissues and their participation in local immune responses.

Original languageEnglish (US)
Pages (from-to)54-58
Number of pages5
JournalInternational Archives of Allergy and Immunology
Volume88
Issue number1-2
DOIs
StatePublished - 1989

Fingerprint

Eosinophils
Immunoglobulin E
Eosinophil Peroxidase
Eosinophil Cationic Protein
IgE Receptors
Antibodies
Allergens
Immunoglobulins
Electron Microscopy
Hypersensitivity
Staining and Labeling
Proteins

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Capron, M., Tomassini, M., Torpier, G., Kusnierz, J. P., MacDonald, S. M., & Capron, A. (1989). Selectivity of mediators released by eosinophils. International Archives of Allergy and Immunology, 88(1-2), 54-58. https://doi.org/10.1159/000234748

Selectivity of mediators released by eosinophils. / Capron, Monique; Tomassini, Margherita; Torpier, Gérard; Kusnierz, Jean Pierre; MacDonald, Susan M; Capron, André.

In: International Archives of Allergy and Immunology, Vol. 88, No. 1-2, 1989, p. 54-58.

Research output: Contribution to journalArticle

Capron, M, Tomassini, M, Torpier, G, Kusnierz, JP, MacDonald, SM & Capron, A 1989, 'Selectivity of mediators released by eosinophils', International Archives of Allergy and Immunology, vol. 88, no. 1-2, pp. 54-58. https://doi.org/10.1159/000234748
Capron, Monique ; Tomassini, Margherita ; Torpier, Gérard ; Kusnierz, Jean Pierre ; MacDonald, Susan M ; Capron, André. / Selectivity of mediators released by eosinophils. In: International Archives of Allergy and Immunology. 1989 ; Vol. 88, No. 1-2. pp. 54-58.
@article{a3be732c620440ca8d790f5024a9db94,
title = "Selectivity of mediators released by eosinophils",
abstract = "The presence of receptors for IgE on eosinophils has drawn the attention on their direct participation in IgE-dependent hypersensitivity reactions. Surface IgE antibodies were detected on eosinophils from allergic patients. The addition of the specific allergen or anti-IgE antibodies to such purified eosinophils induced the release of eosinophil peroxidase, but not of eosinophil cationic protein. These findings associated with results obtained by using electron microscopy and immunogold staining of the various antibodies directed against the granule proteins allowed us to suggest a selectivity in the mediators released by eosinophils. In addition, preliminary results concerning the existence and the functional role of a receptor for IgA on eosinophils are reported, leading to the concept of a particular interaction of eosinophils with immunoglobulins present in the tissues and their participation in local immune responses.",
author = "Monique Capron and Margherita Tomassini and G{\'e}rard Torpier and Kusnierz, {Jean Pierre} and MacDonald, {Susan M} and Andr{\'e} Capron",
year = "1989",
doi = "10.1159/000234748",
language = "English (US)",
volume = "88",
pages = "54--58",
journal = "International Archives of Allergy and Immunology",
issn = "1018-2438",
publisher = "S. Karger AG",
number = "1-2",

}

TY - JOUR

T1 - Selectivity of mediators released by eosinophils

AU - Capron, Monique

AU - Tomassini, Margherita

AU - Torpier, Gérard

AU - Kusnierz, Jean Pierre

AU - MacDonald, Susan M

AU - Capron, André

PY - 1989

Y1 - 1989

N2 - The presence of receptors for IgE on eosinophils has drawn the attention on their direct participation in IgE-dependent hypersensitivity reactions. Surface IgE antibodies were detected on eosinophils from allergic patients. The addition of the specific allergen or anti-IgE antibodies to such purified eosinophils induced the release of eosinophil peroxidase, but not of eosinophil cationic protein. These findings associated with results obtained by using electron microscopy and immunogold staining of the various antibodies directed against the granule proteins allowed us to suggest a selectivity in the mediators released by eosinophils. In addition, preliminary results concerning the existence and the functional role of a receptor for IgA on eosinophils are reported, leading to the concept of a particular interaction of eosinophils with immunoglobulins present in the tissues and their participation in local immune responses.

AB - The presence of receptors for IgE on eosinophils has drawn the attention on their direct participation in IgE-dependent hypersensitivity reactions. Surface IgE antibodies were detected on eosinophils from allergic patients. The addition of the specific allergen or anti-IgE antibodies to such purified eosinophils induced the release of eosinophil peroxidase, but not of eosinophil cationic protein. These findings associated with results obtained by using electron microscopy and immunogold staining of the various antibodies directed against the granule proteins allowed us to suggest a selectivity in the mediators released by eosinophils. In addition, preliminary results concerning the existence and the functional role of a receptor for IgA on eosinophils are reported, leading to the concept of a particular interaction of eosinophils with immunoglobulins present in the tissues and their participation in local immune responses.

UR - http://www.scopus.com/inward/record.url?scp=0024559258&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024559258&partnerID=8YFLogxK

U2 - 10.1159/000234748

DO - 10.1159/000234748

M3 - Article

VL - 88

SP - 54

EP - 58

JO - International Archives of Allergy and Immunology

JF - International Archives of Allergy and Immunology

SN - 1018-2438

IS - 1-2

ER -