TY - JOUR
T1 - Selectivity of mediators released by eosinophils
AU - Capron, Monique
AU - Tomassini, Margherita
AU - Torpier, Gérard
AU - Kusnierz, Jean Pierre
AU - Macdonald, Susan
AU - Capron, André
PY - 1989
Y1 - 1989
N2 - The presence of receptors for IgE on eosinophils has drawn the attention on their direct participation in IgE-dependent hypersensitivity reactions. Surface IgE antibodies were detected on eosinophils from allergic patients. The addition of the specific allergen or anti-IgE antibodies to such purified eosinophils induced the release of eosinophil peroxidase, but not of eosinophil cationic protein. These findings associated with results obtained by using electron microscopy and immunogold staining of the various antibodies directed against the granule proteins allowed us to suggest a selectivity in the mediators released by eosinophils. In addition, preliminary results concerning the existence and the functional role of a receptor for IgA on eosinophils are reported, leading to the concept of a particular interaction of eosinophils with immunoglobulins present in the tissues and their participation in local immune responses.
AB - The presence of receptors for IgE on eosinophils has drawn the attention on their direct participation in IgE-dependent hypersensitivity reactions. Surface IgE antibodies were detected on eosinophils from allergic patients. The addition of the specific allergen or anti-IgE antibodies to such purified eosinophils induced the release of eosinophil peroxidase, but not of eosinophil cationic protein. These findings associated with results obtained by using electron microscopy and immunogold staining of the various antibodies directed against the granule proteins allowed us to suggest a selectivity in the mediators released by eosinophils. In addition, preliminary results concerning the existence and the functional role of a receptor for IgA on eosinophils are reported, leading to the concept of a particular interaction of eosinophils with immunoglobulins present in the tissues and their participation in local immune responses.
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U2 - 10.1159/000234748
DO - 10.1159/000234748
M3 - Article
C2 - 2523359
AN - SCOPUS:0024559258
SN - 1018-2438
VL - 88
SP - 54
EP - 58
JO - International archives of allergy and immunology
JF - International archives of allergy and immunology
IS - 1-2
ER -