Selective serotonin reuptake inhibitors yield additional antiplatelet protection in patients with congestive heart failure treated with antecedent aspirin

V. L. Serebruany; A. H. Glassman; A. I. Malinin; D. Atar; D. C. Sane; B. R. Oshrine; J. J. Ferguson; C. M. O'Connor

doi:10.1016/S1388-9842(03)00005-9

Selective serotonin reuptake inhibitors yield additional antiplatelet protection in patients with congestive heart failure treated with antecedent aspirin

V. L. Serebruany, A. H. Glassman, A. I. Malinin, D. Atar, D. C. Sane, B. R. Oshrine, J. J. Ferguson, C. M. O'Connor

School of Medicine

Research output: Contribution to journal › Article › peer-review

63 Scopus citations

Abstract

Clinical depression has been identified as an independent risk factor for increased mortality in patients with coronary artery disease. Enhanced platelet activity has been suggested as the mechanism responsible for this adverse association. Selective serotonin reuptake inhibitors (SSRIs) are known to inhibit platelets in patients undergoing coronary stenting. We sought to determine whether concomitant therapy with SSRIs would yield additional anti-platelet benefit in patients with congestive heart failure (CHF) already treated with antecedent aspirin. A total of 88 patients with left ventricular ejection fraction (LVEF)

Original language	English (US)
Pages (from-to)	517-521
Number of pages	5
Journal	European Journal of Heart Failure
Volume	5
Issue number	4
DOIs	https://doi.org/10.1016/S1388-9842(03)00005-9
State	Published - Aug 2003

Keywords

Congestive heart failure
Platelets
Selective serotonin reuptake inhibitors (SSRIs)

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/S1388-9842(03)00005-9

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Serebruany, V. L., Glassman, A. H., Malinin, A. I., Atar, D., Sane, D. C., Oshrine, B. R., Ferguson, J. J., & O'Connor, C. M. (2003). Selective serotonin reuptake inhibitors yield additional antiplatelet protection in patients with congestive heart failure treated with antecedent aspirin. European Journal of Heart Failure, 5(4), 517-521. https://doi.org/10.1016/S1388-9842(03)00005-9

Serebruany, VL, Glassman, AH, Malinin, AI, Atar, D, Sane, DC, Oshrine, BR, Ferguson, JJ & O'Connor, CM 2003, 'Selective serotonin reuptake inhibitors yield additional antiplatelet protection in patients with congestive heart failure treated with antecedent aspirin', European Journal of Heart Failure, vol. 5, no. 4, pp. 517-521. https://doi.org/10.1016/S1388-9842(03)00005-9

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abstract = "Clinical depression has been identified as an independent risk factor for increased mortality in patients with coronary artery disease. Enhanced platelet activity has been suggested as the mechanism responsible for this adverse association. Selective serotonin reuptake inhibitors (SSRIs) are known to inhibit platelets in patients undergoing coronary stenting. We sought to determine whether concomitant therapy with SSRIs would yield additional anti-platelet benefit in patients with congestive heart failure (CHF) already treated with antecedent aspirin. A total of 88 patients with left ventricular ejection fraction (LVEF) ",

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year = "2003",

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doi = "10.1016/S1388-9842(03)00005-9",

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T1 - Selective serotonin reuptake inhibitors yield additional antiplatelet protection in patients with congestive heart failure treated with antecedent aspirin

AU - Serebruany, V. L.

AU - Glassman, A. H.

AU - Malinin, A. I.

AU - Atar, D.

AU - Sane, D. C.

AU - Oshrine, B. R.

AU - Ferguson, J. J.

AU - O'Connor, C. M.

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AB - Clinical depression has been identified as an independent risk factor for increased mortality in patients with coronary artery disease. Enhanced platelet activity has been suggested as the mechanism responsible for this adverse association. Selective serotonin reuptake inhibitors (SSRIs) are known to inhibit platelets in patients undergoing coronary stenting. We sought to determine whether concomitant therapy with SSRIs would yield additional anti-platelet benefit in patients with congestive heart failure (CHF) already treated with antecedent aspirin. A total of 88 patients with left ventricular ejection fraction (LVEF)

KW - Congestive heart failure

KW - Platelets

KW - Selective serotonin reuptake inhibitors (SSRIs)

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Selective serotonin reuptake inhibitors yield additional antiplatelet protection in patients with congestive heart failure treated with antecedent aspirin

Abstract

Keywords

ASJC Scopus subject areas

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