Selective Persulfide Detection Reveals Evolutionarily Conserved Antiaging Effects of S-Sulfhydration

Jasmina Zivanovic; Emilia Kouroussis; Joshua B. Kohl; Bikash Adhikari; Biljana Bursac; Sonia Schott-Roux; Dunja Petrovic; Jan Lj Miljkovic; Daniel Thomas-Lopez; Youngeun Jung; Marko Miler; Sarah Mitchell; Verica Milosevic; Jose Eduardo Gomes; Moran Benhar; Bruno Gonzales-Zorn; Ivana Ivanovic-Burmazovic; Roberta Torregrossa; James R. Mitchell; Matthew Whiteman; Guenter Schwarz; Solomon H. Snyder; Bindu D. Paul; Kate S. Carroll; Milos R. Filipovic

doi:10.1016/j.cmet.2019.10.007

Selective Persulfide Detection Reveals Evolutionarily Conserved Antiaging Effects of S-Sulfhydration

Jasmina Zivanovic, Emilia Kouroussis, Joshua B. Kohl, Bikash Adhikari, Biljana Bursac, Sonia Schott-Roux, Dunja Petrovic, Jan Lj Miljkovic, Daniel Thomas-Lopez, Youngeun Jung, Marko Miler, Sarah Mitchell, Verica Milosevic, Jose Eduardo Gomes, Moran Benhar, Bruno Gonzales-Zorn, Ivana Ivanovic-Burmazovic, Roberta Torregrossa, James R. Mitchell, Matthew WhitemanGuenter Schwarz, Solomon H. Snyder, Bindu D. Paul, Kate S. Carroll, Milos R. Filipovic

School of Medicine

Research output: Contribution to journal › Article

Abstract

Zivanovic et al. develop a robust method for chemoselective persulfide labeling using dimedone-based probes to show that persulfidation is an evolutionarily conserved post-translational modification used by the cells to protect proteins from overoxidation caused by different stressors. Higher persulfidation levels, caused by pharmacological or dietary interventions, lead to better resistance to oxidative stress and longer life.

Original language	English (US)
Pages (from-to)	1152-1170.e13
Journal	Cell Metabolism
Volume	30
Issue number	6
DOIs	https://doi.org/10.1016/j.cmet.2019.10.007
State	Published - Dec 3 2019

Keywords

aging
calorie restriction
hydrogen peroxide
hydrogen sulfide
protein persulfidation
redox signaling
sulfenylation
sulfinylation
sulfonylation

ASJC Scopus subject areas

Physiology
Molecular Biology
Cell Biology

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Zivanovic, J., Kouroussis, E., Kohl, J. B., Adhikari, B., Bursac, B., Schott-Roux, S., Petrovic, D., Miljkovic, J. L., Thomas-Lopez, D., Jung, Y., Miler, M., Mitchell, S., Milosevic, V., Gomes, J. E., Benhar, M., Gonzales-Zorn, B., Ivanovic-Burmazovic, I., Torregrossa, R., Mitchell, J. R., ... Filipovic, M. R. (2019). Selective Persulfide Detection Reveals Evolutionarily Conserved Antiaging Effects of S-Sulfhydration. Cell Metabolism, 30(6), 1152-1170.e13. https://doi.org/10.1016/j.cmet.2019.10.007

Selective Persulfide Detection Reveals Evolutionarily Conserved Antiaging Effects of S-Sulfhydration. / Zivanovic, Jasmina; Kouroussis, Emilia; Kohl, Joshua B.; Adhikari, Bikash; Bursac, Biljana; Schott-Roux, Sonia; Petrovic, Dunja; Miljkovic, Jan Lj; Thomas-Lopez, Daniel; Jung, Youngeun; Miler, Marko; Mitchell, Sarah; Milosevic, Verica; Gomes, Jose Eduardo; Benhar, Moran; Gonzales-Zorn, Bruno; Ivanovic-Burmazovic, Ivana; Torregrossa, Roberta; Mitchell, James R.; Whiteman, Matthew; Schwarz, Guenter; Snyder, Solomon H.; Paul, Bindu D.; Carroll, Kate S.; Filipovic, Milos R.

In: Cell Metabolism, Vol. 30, No. 6, 03.12.2019, p. 1152-1170.e13.

Research output: Contribution to journal › Article

Zivanovic, J, Kouroussis, E, Kohl, JB, Adhikari, B, Bursac, B, Schott-Roux, S, Petrovic, D, Miljkovic, JL, Thomas-Lopez, D, Jung, Y, Miler, M, Mitchell, S, Milosevic, V, Gomes, JE, Benhar, M, Gonzales-Zorn, B, Ivanovic-Burmazovic, I, Torregrossa, R, Mitchell, JR, Whiteman, M, Schwarz, G, Snyder, SH , Paul, BD, Carroll, KS & Filipovic, MR 2019, 'Selective Persulfide Detection Reveals Evolutionarily Conserved Antiaging Effects of S-Sulfhydration', Cell Metabolism, vol. 30, no. 6, pp. 1152-1170.e13. https://doi.org/10.1016/j.cmet.2019.10.007

Zivanovic, Jasmina ; Kouroussis, Emilia ; Kohl, Joshua B. ; Adhikari, Bikash ; Bursac, Biljana ; Schott-Roux, Sonia ; Petrovic, Dunja ; Miljkovic, Jan Lj ; Thomas-Lopez, Daniel ; Jung, Youngeun ; Miler, Marko ; Mitchell, Sarah ; Milosevic, Verica ; Gomes, Jose Eduardo ; Benhar, Moran ; Gonzales-Zorn, Bruno ; Ivanovic-Burmazovic, Ivana ; Torregrossa, Roberta ; Mitchell, James R. ; Whiteman, Matthew ; Schwarz, Guenter ; Snyder, Solomon H. ; Paul, Bindu D. ; Carroll, Kate S. ; Filipovic, Milos R. / Selective Persulfide Detection Reveals Evolutionarily Conserved Antiaging Effects of S-Sulfhydration. In: Cell Metabolism. 2019 ; Vol. 30, No. 6. pp. 1152-1170.e13.

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abstract = "Zivanovic et al. develop a robust method for chemoselective persulfide labeling using dimedone-based probes to show that persulfidation is an evolutionarily conserved post-translational modification used by the cells to protect proteins from overoxidation caused by different stressors. Higher persulfidation levels, caused by pharmacological or dietary interventions, lead to better resistance to oxidative stress and longer life.",

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AU - Bursac, Biljana

AU - Schott-Roux, Sonia

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AU - Miljkovic, Jan Lj

AU - Thomas-Lopez, Daniel

AU - Jung, Youngeun

AU - Miler, Marko

AU - Mitchell, Sarah

AU - Milosevic, Verica

AU - Gomes, Jose Eduardo

AU - Benhar, Moran

AU - Gonzales-Zorn, Bruno

AU - Ivanovic-Burmazovic, Ivana

AU - Torregrossa, Roberta

AU - Mitchell, James R.

AU - Whiteman, Matthew

AU - Schwarz, Guenter

AU - Snyder, Solomon H.

AU - Paul, Bindu D.

AU - Carroll, Kate S.

AU - Filipovic, Milos R.

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KW - calorie restriction

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