@article{035ad985e30340e5a75400f969abf885,
title = "Selective Persulfide Detection Reveals Evolutionarily Conserved Antiaging Effects of S-Sulfhydration",
abstract = "Zivanovic et al. develop a robust method for chemoselective persulfide labeling using dimedone-based probes to show that persulfidation is an evolutionarily conserved post-translational modification used by the cells to protect proteins from overoxidation caused by different stressors. Higher persulfidation levels, caused by pharmacological or dietary interventions, lead to better resistance to oxidative stress and longer life.",
keywords = "aging, calorie restriction, hydrogen peroxide, hydrogen sulfide, protein persulfidation, redox signaling, sulfenylation, sulfinylation, sulfonylation",
author = "Jasmina Zivanovic and Emilia Kouroussis and Kohl, {Joshua B.} and Bikash Adhikari and Biljana Bursac and Sonia Schott-Roux and Dunja Petrovic and Miljkovic, {Jan Lj} and Daniel Thomas-Lopez and Youngeun Jung and Marko Miler and Sarah Mitchell and Verica Milosevic and Gomes, {Jose Eduardo} and Moran Benhar and Bruno Gonzales-Zorn and Ivana Ivanovic-Burmazovic and Roberta Torregrossa and Mitchell, {James R.} and Matthew Whiteman and Guenter Schwarz and Snyder, {Solomon H.} and Paul, {Bindu D.} and Carroll, {Kate S.} and Filipovic, {Milos R.}",
note = "Funding Information: The authors would like to thank Dr. Michel Toledano for careful reading of the manuscript and helpful discussions and Dr. Bertrand Daignan-Fornier for his help with yeast experiments. Funding: this work was supported by the ATIP -Avenir grant, by the French State in the frame of the “Investments for the future” Programme IdEx Bordeaux ( ANR-10-IDEX-03-02 ) and by FRM ( DEQ20180339181 ). M.W. acknowledges support from MRC , UK ( MR/M022706/1 ), the Brian Ridge Scholarship (to R.T.), and the Northcott Devon Medical Research Foundation , UK. M.M. and V.M. were supported by the Ministry of Education, Science and Technology Development of the Republic of Serbia ( 173009 ). K.S.C. acknowledges support by NIH ( GM102187 ). G.S. and J.B.K. acknowledge support by the DFG , Germany ( SFB1218 TP B08 ). Project 19PABH134580006 from the AHA/Allen Initiative in Brain Health and Cognitive Impairment team (SHS and associates) is acknowledged. Funding Information: The authors would like to thank Dr. Michel Toledano for careful reading of the manuscript and helpful discussions and Dr. Bertrand Daignan-Fornier for his help with yeast experiments. Funding: this work was supported by the ATIP-Avenir grant, by the French State in the frame of the ?Investments for the future? Programme IdEx Bordeaux (ANR-10-IDEX-03-02) and by FRM (DEQ20180339181). M.W. acknowledges support from MRC, UK (MR/M022706/1), the Brian Ridge Scholarship (to R.T.), and the Northcott Devon Medical Research Foundation, UK. M.M. and V.M. were supported by the Ministry of Education, Science and Technology Development of the Republic of Serbia (173009). K.S.C. acknowledges support by NIH (GM102187). G.S. and J.B.K. acknowledge support by the DFG, Germany (SFB1218 TP B08). Project 19PABH134580006 from the AHA/Allen Initiative in Brain Health and Cognitive Impairment team (SHS and associates) is acknowledged. M.R.F. conceived the study. The key experiments were performed by both J.Z. and E.K. with distinction that J.Z. performed lifespan experiments and EGFR activation, while E.K. performed stress assays and VEGF and insulin activation experiments. J.B.K. B.A. S.S.-R. D.T.-L. J.Lj.M. B.B. D.P. M.M. B.D.P. and M.R.F. also performed experiments. Y.G. K.C. R.T. M.W. M.B. V.M. I.I.-B. G.S. J.E.G. B.G.Z. B.P. and S.H.S. provided tools and intellectual input and helped with data analysis. S.M. and J.M. provided DR mouse livers and helped with data analysis. M.R.F. wrote the manuscript with the help from all co-authors. M.W. and the University of Exeter have patents on the therapeutic and agricultural use of mitochondria-targeted, and other, hydrogen sulfide delivery molecules. All other authors declare no competing interests. Publisher Copyright: {\textcopyright} 2019",
year = "2019",
month = dec,
day = "3",
doi = "10.1016/j.cmet.2019.10.007",
language = "English (US)",
volume = "30",
pages = "1152--1170.e13",
journal = "Cell Metabolism",
issn = "1550-4131",
publisher = "Cell Press",
number = "6",
}