Selective NR2B NMDA receptor antagonists are protective against staurosporine-induced apoptosis

Anthony J. Williams, Jitendra R. Dave, X. May Lu, Geoff Ling, Frank C. Tortella

Research output: Contribution to journalArticle

Abstract

Staurosporine-induced apoptosis was associated with a 20% cellular survival rate in primary rat forebrain cultures. Treatment with the NR2B subunit-selective NMDA receptor antagonist conantokin-G (0.1-1 μM) increased the survival rate up to 78%. No protection was provided by the nonselective NMDA receptor antagonist dizocilpine (0.01-10 μM) but 34-64% cellular survival was provided by ifenprodil (0.01-10 μM), another NR2B subunit-selective antagonist. These results suggest a novel anti-apoptotic mechanism linked to the NR2B receptor subunit.

Original languageEnglish (US)
Pages (from-to)135-136
Number of pages2
JournalEuropean Journal of Pharmacology
Volume452
Issue number1
DOIs
StatePublished - Sep 27 2002

Keywords

  • Conantokin-G
  • Neuronal culture
  • Staurosporine

ASJC Scopus subject areas

  • Pharmacology

Fingerprint Dive into the research topics of 'Selective NR2B NMDA receptor antagonists are protective against staurosporine-induced apoptosis'. Together they form a unique fingerprint.

  • Cite this