Selective loss of pattern discrimination in early glaucoma

Bruce A. Drum, Matthew Severns, David K. O'leary, Robert W Massof, Harry A Quigley, Michael E. Breton, Theodore Krupin

Research output: Contribution to journalArticlepeer-review

Abstract

A new perimetric pattern discrimination test was compared with conventional automated perimetry (Humphrey program 30-2 or Octopus program 32) in glaucoma patients, glaucoma suspects, and control subjects. The new test is based on the rationale that a greater percentage of retinal ganglion cells should be needed to detect a stimulus by its shape, or pattern, than by its brightness. The pattern discrimination stimulus was a patch of nonrandom dots embedded in a surrounding random dot field of the same average density. Pattern discrimination thresholds were measured by changing the degree of regularity, or coherence, of the stimulus dots. The fully coherent target was a static, 1-s duration, 20 × 20-dot checkerboard. Using a criterion-free relative operating characteristic analysis, we estimated the ability of both the pattern discrimination and conventional tests to distinguish the normal data distribution from the suspect and glaucoma distributions. The pattern discrimination test appeared to produce separations greater than conventional perimetry for glaucoma suspects and separations equivalent to conventional perimetry for glaucoma patients.

Original languageEnglish (US)
Pages (from-to)1135-1144
Number of pages10
JournalApplied Optics
Volume28
Issue number6
DOIs
StatePublished - Mar 15 1989

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics

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