@article{efa778519ee744de99c978a5c7e81149,
title = "Selective Inhibition of Thromboxane Synthesis in Glycerol-Induced Acute Renal Failure",
abstract = "It has recently been postulated that thromboxame A2 may participate in the pathogenesis of acute myohemoglobinuric experimental acute renal failure. To investigate this further, the effect of selective inhibition of thromboxane synthesis on the course of glycerol-induced acute renal failure was determined. Despite significant inhibition of thromboxane synthesis by 4-imidazole-yl-acetophenone, the functional and morphologic disturbance induced by glycerol was unaltered. Moreover, pretreatment with 4-imidazole-yl-acetophenone failed to prevent the fall in renal blood flow seen following glycerol administration. These results argue against a major role for thromboxane A2 in the pathogenesis of this form of experimental acute renal failure.",
keywords = "Glycerol, acute renal failure, renal blood flow, thromboxane",
author = "Watson, {Alan J.} and Stout, {Robert L.} and Adkinson, {N. Franklin} and Kim Solez and Andrew Whelton",
note = "Funding Information: From the Departments of Medicine and Pathology, fohns Hopkins Unversity School of Medicine, Baltimore. Sponsored in part by NIH Grant No. 5MOIRR35-20. Address reprint requests 10 Alan f. Watson, MD, Marburg 401, fohns Hopkins Hospital, 6()() North Wolfe St, Baltimore. MD 21205. {\textcopyright} 1986 by (hI! National Kidney Foundation. Inc. 0272-6386/86/0801-0003$03.00/0 Funding Information: described. 14 Serum and urinary creatinine determinations were done by an adaptation of the methodology described by Van Pilsum.{"} Light microscopic evaluation of the renal tissue was undertaken to quantify the degree of renal morphologic damage in the animals incorporated in studies I and 2. The technique of tubular necrosis ranking, as previously described for our laboratories, provided a means of quantifying and statistically comparing intra-and intergroup renal morphologic changes. I{"} Statistical analyses using appropriate parametric and nonparametric analyses were performed using the CLINFO computer system (sponsored by NIH Grant 5MOIRR35-20). Copyright: Copyright 2017 Elsevier B.V., All rights reserved.",
year = "1986",
doi = "10.1016/S0272-6386(86)80150-0",
language = "English (US)",
volume = "8",
pages = "26--30",
journal = "American Journal of Kidney Diseases",
issn = "0272-6386",
publisher = "W.B. Saunders Ltd",
number = "1",
}