Selective Inhibition of Thromboxane Synthesis in Glycerol-Induced Acute Renal Failure

Alan J. Watson, Robert L. Stout, N. Franklin Adkinson, Kim Solez, Andrew Whelton

Research output: Contribution to journalArticlepeer-review


It has recently been postulated that thromboxame A2 may participate in the pathogenesis of acute myohemoglobinuric experimental acute renal failure. To investigate this further, the effect of selective inhibition of thromboxane synthesis on the course of glycerol-induced acute renal failure was determined. Despite significant inhibition of thromboxane synthesis by 4-imidazole-yl-acetophenone, the functional and morphologic disturbance induced by glycerol was unaltered. Moreover, pretreatment with 4-imidazole-yl-acetophenone failed to prevent the fall in renal blood flow seen following glycerol administration. These results argue against a major role for thromboxane A2 in the pathogenesis of this form of experimental acute renal failure.

Original languageEnglish (US)
Pages (from-to)26-30
Number of pages5
JournalAmerican Journal of Kidney Diseases
Issue number1
StatePublished - 1986


  • Glycerol
  • acute renal failure
  • renal blood flow
  • thromboxane

ASJC Scopus subject areas

  • Nephrology


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