Selective inhibition of E. coli 1-deoxy-d-xylulose-5-phosphate synthase by acetylphosphonates

Jessica M. Smith, Ryan J. Vierling, Caren Freel Meyers

Research output: Contribution to journalArticlepeer-review


DXP synthase catalyzes the formation of 1-deoxy-d-xylulose 5-phosphate, an essential precursor in pathogen isoprenoid biosynthesis. The selective inhibition of this ThDP-dependent transformation is a challenging goal in the development of isoprenoid biosynthesis inhibitors. Potent, selective inhibitors could lead to new anti-infective agents. Here, we demonstrate selective inhibition of E. coli DXP synthase by butylacetylphosphonate.

Original languageEnglish (US)
Pages (from-to)65-67
Number of pages3
Issue number1
StatePublished - Jan 2012

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Pharmacology
  • Pharmaceutical Science
  • Drug Discovery
  • Organic Chemistry


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