Selective immunotoxic lesions of basal forebrain cholinergic cells: Effects on learning and memory in rats

Mark G. Baxter, David J. Bucci, Linda K. Gorman, Ronald G. Wiley, Michela Gallagher

Research output: Contribution to journalArticle

Abstract

Male Long-Evans rats were given injections of either 192 IgG-saporin, an apparently selective toxin for basal forebrain cholinergic neurons (LES), or vehicle (CON) into either the medial septum and vertical limb of the diagonal band (MS/VDB) or bilaterally into the nucleus basalis magnocellularis and substantia innominata (nBM/SI). Place discrimination in the Morris water maze assessed spatial learning, and a trial-unique matching-to-place task in the water maze assessed memory for place information over varying delays. MS/VDB-LES and nBM/SI-LES rats were not impaired relative to CON rats in acquisition of the place discrimination, but were mildly impaired relative to CON rats in performance of the memory task even at the shortest delay, suggesting a nonmnemonic deficit. These results contrast with effects of less selective lesions, which have been taken to support a role for basal forebrain cholinergic neurons in learning and memory.

Original languageEnglish (US)
Pages (from-to)619-627
Number of pages9
JournalBehavioral Neuroscience
Volume127
Issue number5
DOIs
StatePublished - Oct 2013
Externally publishedYes

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Substantia Innominata
Basal Nucleus of Meynert
Cholinergic Agents
Cholinergic Neurons
Learning
Extremities
Long Evans Rats
Water
Task Performance and Analysis
Injections
Basal Forebrain
Discrimination (Psychology)

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Selective immunotoxic lesions of basal forebrain cholinergic cells : Effects on learning and memory in rats. / Baxter, Mark G.; Bucci, David J.; Gorman, Linda K.; Wiley, Ronald G.; Gallagher, Michela.

In: Behavioral Neuroscience, Vol. 127, No. 5, 10.2013, p. 619-627.

Research output: Contribution to journalArticle

Baxter, Mark G. ; Bucci, David J. ; Gorman, Linda K. ; Wiley, Ronald G. ; Gallagher, Michela. / Selective immunotoxic lesions of basal forebrain cholinergic cells : Effects on learning and memory in rats. In: Behavioral Neuroscience. 2013 ; Vol. 127, No. 5. pp. 619-627.
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