Abstract
Objective: To explore development of possible approaches leading to a sensitive and precise Medline search to identify observational studies of the association between oral contraceptives and breast cancer, an adverse event. Study Design and Setting: We compared the results of a series of Medline searches to a gold standard comprising 58 reports from a 1996 systematic review examining the relationship between oral contraceptives and the development of breast cancer. Sensitivity (the proportion of gold standard publications identified) and precision (the proportion of retrieved publications that were included in the gold standard) were calculated for each Medline search. Results: We identified all 58 articles when the search was not limited by terms related to oral contraceptives, but precision was less than 1% (58 of 6,120). Indexing was problematic when oral contraceptives or hormones were not mentioned in the title or abstract (n = 8) or full text (n = 2). Conclusion: Search strategies identifying all relevant studies were possible but arguably impractical; additional research is needed to generalize our findings. Authors and editors should ensure that all interventions and outcomes examined are reported and indexers should make sure they are indexed. Central registration of observational studies and all variables they examined should be considered to assure identification of studies examining adverse events associated with health interventions.
Original language | English (US) |
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Pages (from-to) | 560-567 |
Number of pages | 8 |
Journal | Journal of Clinical Epidemiology |
Volume | 58 |
Issue number | 6 |
DOIs | |
State | Published - Jun 2005 |
Externally published | Yes |
Keywords
- Adverse events
- Information storage and retrieval
- Medline searching
- Observational studies
- Precision
- Sensitivity
- Systematic reviews
ASJC Scopus subject areas
- Epidemiology