Selective exposure reporting and Medline indexing limited the search sensitivity for observational studies of the adverse effects of oral contraceptives

Susan Wieland, Kay Dickersin

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To explore development of possible approaches leading to a sensitive and precise Medline search to identify observational studies of the association between oral contraceptives and breast cancer, an adverse event. Study Design and Setting: We compared the results of a series of Medline searches to a gold standard comprising 58 reports from a 1996 systematic review examining the relationship between oral contraceptives and the development of breast cancer. Sensitivity (the proportion of gold standard publications identified) and precision (the proportion of retrieved publications that were included in the gold standard) were calculated for each Medline search. Results: We identified all 58 articles when the search was not limited by terms related to oral contraceptives, but precision was less than 1% (58 of 6,120). Indexing was problematic when oral contraceptives or hormones were not mentioned in the title or abstract (n = 8) or full text (n = 2). Conclusion: Search strategies identifying all relevant studies were possible but arguably impractical; additional research is needed to generalize our findings. Authors and editors should ensure that all interventions and outcomes examined are reported and indexers should make sure they are indexed. Central registration of observational studies and all variables they examined should be considered to assure identification of studies examining adverse events associated with health interventions.

Original languageEnglish (US)
Pages (from-to)560-567
Number of pages8
JournalJournal of Clinical Epidemiology
Volume58
Issue number6
DOIs
StatePublished - Jun 2005
Externally publishedYes

Keywords

  • Adverse events
  • Information storage and retrieval
  • Medline searching
  • Observational studies
  • Precision
  • Sensitivity
  • Systematic reviews

ASJC Scopus subject areas

  • Epidemiology

Fingerprint Dive into the research topics of 'Selective exposure reporting and Medline indexing limited the search sensitivity for observational studies of the adverse effects of oral contraceptives'. Together they form a unique fingerprint.

Cite this