Selective endothelial growth inhibition by tetracyclines that inhibit collagenase

Christopher Guerin, John Laterra, Taras Masnyk, Lorne M. Golub, Henry Brem

Research output: Contribution to journalArticlepeer-review

Abstract

The potential of angiogenesis inhibitors as therapy for human diseases is limited by a lack of clinically available agents. We investigated the mechanism of the anti-angiogenesis effects of minocycline, a commonly used drug, and several derivatives. Endothelial cell proliferation was inhibited by several of these compounds. We found that inhibition was associated with inhibition of collagenase, did not require antibiotic activity, and was not related to cytotoxicity. Other microvessel-associated cells were unaffected. This endothelial antiproliferative effect is a potential mechanism of the anti-angiogenic activity of minocycline.

Original languageEnglish (US)
Pages (from-to)740-745
Number of pages6
JournalBiochemical and Biophysical Research Communications
Volume188
Issue number2
DOIs
StatePublished - Oct 30 1992

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

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