Selective effects of interleukin (IL)-15 on antifungal activity and IL-8 release by polymorphonuclear leukocytes in response to hyphae of Aspergillus species

Richard M. Winn, Cristina Gil-Lamaignere, Emmanuel Roilides, Maria Simitsopoulou, Caron A. Lyman, Avgi Maloukou, Thomas J. Walsh

Research output: Contribution to journalArticle

Abstract

The effects of interleukin (IL)-15 on human polymorphonuclear leukocyte (PMNL) activity against Aspergillus fumigatus and Aspergillus flavus were investigated. Pretreatment with IL-15 for 2 h increased PMNL oxidative burst, as measured by superoxide anion (O2-) release in response to A. fumigatus (P < .05) but not to A. flavus. However, after 22-h, but not 2-h, treatment with IL-15, there was significant enhancement in PMNL-mediated hyphal damage to A. fumigatus. Furthermore, 22-h exposure to IL-15 mediated an enhanced release of IL-8 from PMNLs challenged with hyphae of A. fumigatus and A. flavus (P < .05). In contrast, IL-15 treatment did not affect the release of tumor necrosis factor-α from PMNLs. The selective time- and species-dependent enhancement of O2- production and hyphal damage, as well as its induction of IL-8 release, suggest that IL-15 may play an important role in the immunomodulation of host response to invasive aspergillosis.

Original languageEnglish (US)
Pages (from-to)585-590
Number of pages6
JournalJournal of Infectious Diseases
Volume188
Issue number4
DOIs
StatePublished - Aug 15 2003

ASJC Scopus subject areas

  • Immunology and Allergy
  • Infectious Diseases

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