Selective effects of an NMDA glutamate receptor antagonist on the sensory input from chemoreceptors in the snail's head during acquisition of nociceptive sensitization

V. P. Nikitin, S. A. Koryzev, Alexey Shevelkin

Research output: Contribution to journalArticle

Abstract

Experiments on semi-intact preparations from common snails were used to study the characteristics of the actions of MK-801, an antagonist of NMDA glutamate receptors, on the plasticity of various sensory inputs to defensive behavior command neurons LP11 and RP11 during acquisition of nociceptive sensitization. Application of sensitizing stimuli to the head or foot of control snails led to depression of neuron responses to tactile and chemical sensory stimulation during the short-term stage and marked facilitation of these responses during the long-term stage of sensitization. Application of sensitizing stimuli to the snail's head during administration of MK-801 led to marked depression of responses to chemical stimulation of the head in both the short-term and long-term stages of sensitization. In addition, blockade of NMDA receptors during application of sensitizing stimuli to the foot or head had no effect on changes in neuron responses elicited by chemical stimulation of the snail's foot and by tactile stimulation of the foot or head. It is suggested that NMDA-like glutamate receptors are selectively involved in the mechanism of induction of plasticity of synaptic inputs to command neurons LP11 and RP11, excited by chemical sensory stimulation of the head - a skin receptor zone specific for these neurons.

Original languageEnglish (US)
Pages (from-to)129-134
Number of pages6
JournalNeuroscience and Behavioral Physiology
Volume32
Issue number2
DOIs
StatePublished - Apr 22 2002
Externally publishedYes

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Excitatory Amino Acid Antagonists
Snails
N-Methyl-D-Aspartate Receptors
Chemical Stimulation
Head
Foot
Neurons
Dizocilpine Maleate
Touch
Neuronal Plasticity
Glutamate Receptors
N-Methylaspartate
Skin

ASJC Scopus subject areas

  • Physiology
  • Neuroscience(all)

Cite this

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abstract = "Experiments on semi-intact preparations from common snails were used to study the characteristics of the actions of MK-801, an antagonist of NMDA glutamate receptors, on the plasticity of various sensory inputs to defensive behavior command neurons LP11 and RP11 during acquisition of nociceptive sensitization. Application of sensitizing stimuli to the head or foot of control snails led to depression of neuron responses to tactile and chemical sensory stimulation during the short-term stage and marked facilitation of these responses during the long-term stage of sensitization. Application of sensitizing stimuli to the snail's head during administration of MK-801 led to marked depression of responses to chemical stimulation of the head in both the short-term and long-term stages of sensitization. In addition, blockade of NMDA receptors during application of sensitizing stimuli to the foot or head had no effect on changes in neuron responses elicited by chemical stimulation of the snail's foot and by tactile stimulation of the foot or head. It is suggested that NMDA-like glutamate receptors are selectively involved in the mechanism of induction of plasticity of synaptic inputs to command neurons LP11 and RP11, excited by chemical sensory stimulation of the head - a skin receptor zone specific for these neurons.",
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AB - Experiments on semi-intact preparations from common snails were used to study the characteristics of the actions of MK-801, an antagonist of NMDA glutamate receptors, on the plasticity of various sensory inputs to defensive behavior command neurons LP11 and RP11 during acquisition of nociceptive sensitization. Application of sensitizing stimuli to the head or foot of control snails led to depression of neuron responses to tactile and chemical sensory stimulation during the short-term stage and marked facilitation of these responses during the long-term stage of sensitization. Application of sensitizing stimuli to the snail's head during administration of MK-801 led to marked depression of responses to chemical stimulation of the head in both the short-term and long-term stages of sensitization. In addition, blockade of NMDA receptors during application of sensitizing stimuli to the foot or head had no effect on changes in neuron responses elicited by chemical stimulation of the snail's foot and by tactile stimulation of the foot or head. It is suggested that NMDA-like glutamate receptors are selectively involved in the mechanism of induction of plasticity of synaptic inputs to command neurons LP11 and RP11, excited by chemical sensory stimulation of the head - a skin receptor zone specific for these neurons.

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