TY - JOUR
T1 - Selective decrease in circulating V α24+V β11+ NKT cells during HIV type 1 infection
AU - Van der Vliet, Hans J J
AU - Von Blomberg, B. Mary E
AU - Hazenberg, Mette D.
AU - Nishi, Nobusuke
AU - Otto, Sigrid A.
AU - Van Benthem, Birgit H.
AU - Prins, Maria
AU - Claessen, Frans A.
AU - Van den Eertwegh, Alfons J M
AU - Giaccone, Giuseppe
AU - Miedema, Frank
AU - Scheper, Rik J.
AU - Pinedo, Herbert M.
PY - 2002/2/1
Y1 - 2002/2/1
N2 - CD1d-restricted NKT cells express an invariant TCR and have been demonstrated to play an important regulatory role in a variety of immune responses. Invariant NKT cells down-regulate autoimmune responses by production of type 2 cytokines and can initiate antitumor and antimicrobial immune responses by production of type 1 cytokines. Although defects in the (invariant) V α24+V β11+ NKT cell population have been observed in patients with cancer and autoimmune diseases, little is known regarding the protective role of V α24+V β11+ NKT cells in human infectious disease. In a cross-sectional study in HIV-1-infected individuals, we found circulating numbers of V α24+V β11+ NKT cells to be reduced, independent of CD4+ T cell counts, CD4:CD8 ratios, and viral load. Because a small minority of V α24+V β11+ NKT cells of healthy donors expressed HIV-1 (co)receptors and the vast majority of V α24+V β11+ NKT cells in HIV-1-infected individuals expressed the Fas receptor, the depletion was more likely due to Fas-mediated apoptosis than to preferential infection of V α24+V β11+ NKT cells by HIV-1. A longitudinal cohort study, in which patients were analyzed before seroconversion and 1 and 5 years after seroconversion, demonstrated that a large proportion of the depletion occurred within the first year postseroconversion. In this longitudinal study no evidence was found to support an important role of V α24+V β11+ NKT cells in determining the rate of progression during HIV-1 infection.
AB - CD1d-restricted NKT cells express an invariant TCR and have been demonstrated to play an important regulatory role in a variety of immune responses. Invariant NKT cells down-regulate autoimmune responses by production of type 2 cytokines and can initiate antitumor and antimicrobial immune responses by production of type 1 cytokines. Although defects in the (invariant) V α24+V β11+ NKT cell population have been observed in patients with cancer and autoimmune diseases, little is known regarding the protective role of V α24+V β11+ NKT cells in human infectious disease. In a cross-sectional study in HIV-1-infected individuals, we found circulating numbers of V α24+V β11+ NKT cells to be reduced, independent of CD4+ T cell counts, CD4:CD8 ratios, and viral load. Because a small minority of V α24+V β11+ NKT cells of healthy donors expressed HIV-1 (co)receptors and the vast majority of V α24+V β11+ NKT cells in HIV-1-infected individuals expressed the Fas receptor, the depletion was more likely due to Fas-mediated apoptosis than to preferential infection of V α24+V β11+ NKT cells by HIV-1. A longitudinal cohort study, in which patients were analyzed before seroconversion and 1 and 5 years after seroconversion, demonstrated that a large proportion of the depletion occurred within the first year postseroconversion. In this longitudinal study no evidence was found to support an important role of V α24+V β11+ NKT cells in determining the rate of progression during HIV-1 infection.
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M3 - Article
C2 - 11801694
AN - SCOPUS:0036467364
SN - 0022-1767
VL - 168
SP - 1490
EP - 1495
JO - Journal of Immunology
JF - Journal of Immunology
IS - 3
ER -