Selective cortical and hippocampal volume correlates of Mattis Dementia Rating Scale in Alzheimer disease

Rosemary Fama, Edith V. Sullivan, Paula K. Shear, Laura Marsh, Jerome A. Yesavage, Jared R. Tinklenberg, Kelvin O. Lim, Adolf Pjefferbaum

Research output: Contribution to journalArticle

Abstract

Objective: To examine whether each of the 5 Mattis Dementia Rating Scale (DRS) scores related to magnetic resonance imaging-derived volumes of specific cortical or limbic brain regions in patients with Alzheimer disease (AD). Design: Relations between DRS measures and regional brain volume measures were tested with bivariate and multivariate regression analyses. Setting: The Aging Clinical Research Center of the Stanford (Calif) University Department of Psychiatry and Behavioral Science and the Geriatric Psychiatry Rehabilitation Unit of the Veterans Affairs Palo Alto Health Care System, Palo Alto, Calif. Patients and Other Participants: Fifty patients with possible or probable AD. Magnetic resonance imaging data from 136 healthy control participants, age 20 to 84 years, were used to correct brain volumes for normal variation arising from intracranial volume and age. Main Outcome Measures: The DRS scores and volumes of regional cortical gray matter and of the hippocampus. Results: Memory scores of the patients with AD were selectively related to hippocampal volumes. Attention and construction scores were related to several anterior brain volume measures, with attention showing a significantly greater association to right than left hemisphere measures. Initiation/perseveration scores were not significantly correlated with any measure of regional gray matter volume, but performance was related to prefrontal sulcal widening, with a greater association with the left than right sulcal volume. Conclusions:Certain DRS subtests are predictably correlated with selective regional brain volumes in AD. The specific relation between memory and hippocampal volumes and the nonsignificant relations between memory and regional cortical volumes suggest a dissociation between cortical and hippocampal contributions to explicit memory performance.

Original languageEnglish (US)
Pages (from-to)719-728
Number of pages10
JournalArchives of Neurology
Volume54
Issue number6
StatePublished - 1997
Externally publishedYes

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Dementia
Alzheimer Disease
Brain
Magnetic Resonance Imaging
Behavioral Sciences
Geriatric Psychiatry
Veterans
Psychiatry
Hippocampus
Healthy Volunteers
Rehabilitation
Multivariate Analysis
Regression Analysis
Outcome Assessment (Health Care)
Alzheimer's Disease
Rating Scales
Delivery of Health Care
Research
Gray Matter
Grey Matter

ASJC Scopus subject areas

  • Neuroscience(all)

Cite this

Fama, R., Sullivan, E. V., Shear, P. K., Marsh, L., Yesavage, J. A., Tinklenberg, J. R., ... Pjefferbaum, A. (1997). Selective cortical and hippocampal volume correlates of Mattis Dementia Rating Scale in Alzheimer disease. Archives of Neurology, 54(6), 719-728.

Selective cortical and hippocampal volume correlates of Mattis Dementia Rating Scale in Alzheimer disease. / Fama, Rosemary; Sullivan, Edith V.; Shear, Paula K.; Marsh, Laura; Yesavage, Jerome A.; Tinklenberg, Jared R.; Lim, Kelvin O.; Pjefferbaum, Adolf.

In: Archives of Neurology, Vol. 54, No. 6, 1997, p. 719-728.

Research output: Contribution to journalArticle

Fama, R, Sullivan, EV, Shear, PK, Marsh, L, Yesavage, JA, Tinklenberg, JR, Lim, KO & Pjefferbaum, A 1997, 'Selective cortical and hippocampal volume correlates of Mattis Dementia Rating Scale in Alzheimer disease', Archives of Neurology, vol. 54, no. 6, pp. 719-728.
Fama R, Sullivan EV, Shear PK, Marsh L, Yesavage JA, Tinklenberg JR et al. Selective cortical and hippocampal volume correlates of Mattis Dementia Rating Scale in Alzheimer disease. Archives of Neurology. 1997;54(6):719-728.
Fama, Rosemary ; Sullivan, Edith V. ; Shear, Paula K. ; Marsh, Laura ; Yesavage, Jerome A. ; Tinklenberg, Jared R. ; Lim, Kelvin O. ; Pjefferbaum, Adolf. / Selective cortical and hippocampal volume correlates of Mattis Dementia Rating Scale in Alzheimer disease. In: Archives of Neurology. 1997 ; Vol. 54, No. 6. pp. 719-728.
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