Selective coronary artery plaque visualization and differentiation by contrast-enhanced inversion prepared MRI

David Maintz, Murat Ozgun, Andreas Hoffmeier, Roman Fischbach, Won Yong Kim, Matthias Stuber, Warren J. Manning, Walter Heindel, René M. Botnar

Research output: Contribution to journalArticle

Abstract

Aims: We sought to evaluate the utility of contrast-enhanced coronary magnetic resonance imaging (CE-MRI) for selective visualization and non-invasive differentiation of atherosclerotic coronary plaque in humans. Methods and results: Nine patients with coronary artery disease (CAD) as confirmed by X-ray angiography and multidetector computed tomography (MDCT) were studied by T1-weighted black blood inversion recovery coronary MRI before (N-IR) and after administration of Gd-DTPA (CE-IR). Plaques were categorized as calcified, non-calcified, and mixed based on their Hounsfield number derived from MDCT. With MDCT, a total of 29 plaques were identified, including calcified (n=6), non-calcified (n=6), and mixed calcified/non-calcified (n=17). On N-IR MRI, 26 plaques (90%) were dark, whereas three plaques (two non-calcified and one mixed) appeared bright. On CE-MRI, 13/29 (45%) plaques, 11 of which were mixed, one non-calcified, and one calcified showed contrast uptake. All others remained dark. Conclusion: In this preliminary study, we demonstrate the potential utility of CE-IR MRI for selective plaque visualization and differentiation of plaque types. The observed contrast uptake may be associated with endothelial dysfunction, neovascularization, inflammation, and/or fibrosis.

Original languageEnglish (US)
Pages (from-to)1732-1736
Number of pages5
JournalEuropean Heart Journal
Volume27
Issue number14
DOIs
StatePublished - Jul 2006

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Multidetector Computed Tomography
Coronary Vessels
Magnetic Resonance Imaging
Gadolinium DTPA
X Ray Computed Tomography
Atherosclerotic Plaques
Coronary Artery Disease
Angiography
Fibrosis
Inflammation

Keywords

  • Contrast enhancement
  • Coronary plaque
  • Magnetic resonance imaging
  • Plaque characterization

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Maintz, D., Ozgun, M., Hoffmeier, A., Fischbach, R., Kim, W. Y., Stuber, M., ... Botnar, R. M. (2006). Selective coronary artery plaque visualization and differentiation by contrast-enhanced inversion prepared MRI. European Heart Journal, 27(14), 1732-1736. https://doi.org/10.1093/eurheartj/ehl102

Selective coronary artery plaque visualization and differentiation by contrast-enhanced inversion prepared MRI. / Maintz, David; Ozgun, Murat; Hoffmeier, Andreas; Fischbach, Roman; Kim, Won Yong; Stuber, Matthias; Manning, Warren J.; Heindel, Walter; Botnar, René M.

In: European Heart Journal, Vol. 27, No. 14, 07.2006, p. 1732-1736.

Research output: Contribution to journalArticle

Maintz, D, Ozgun, M, Hoffmeier, A, Fischbach, R, Kim, WY, Stuber, M, Manning, WJ, Heindel, W & Botnar, RM 2006, 'Selective coronary artery plaque visualization and differentiation by contrast-enhanced inversion prepared MRI', European Heart Journal, vol. 27, no. 14, pp. 1732-1736. https://doi.org/10.1093/eurheartj/ehl102
Maintz, David ; Ozgun, Murat ; Hoffmeier, Andreas ; Fischbach, Roman ; Kim, Won Yong ; Stuber, Matthias ; Manning, Warren J. ; Heindel, Walter ; Botnar, René M. / Selective coronary artery plaque visualization and differentiation by contrast-enhanced inversion prepared MRI. In: European Heart Journal. 2006 ; Vol. 27, No. 14. pp. 1732-1736.
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