Selective androgen receptor modulators

In pursuit of tissue-selective androgens

Josephat Omwancha, Terry R. Brown

Research output: Contribution to journalArticle

Abstract

The androgen receptor mediates the androgenic and anabolic activity of the endogenous steroids testosterone and 5α-dihydrotestosterone. Current knowledge of the androgen receptor protein structure, and the molecular mechanisms surrounding the binding properties and activities of agonists and antagonists has led to the design and development of novel nonsteroidal ligands with selected tissue-specific androgen receptor agonist and antagonist activities. The activity of these compounds, termed selective androgen receptor modulators (SARMs), is directed toward the maintenance or enhancement of anabolic effects on bone and muscle with minimal androgenic effects on prostate growth. SARMs are of potential therapeutic value in the treatment of male hypogonadism, osteoporosis, frailty and muscle wasting, burn injury and would healing, anemia, mood and depression, benign prostatic hyperplasia and prostate cancer.

Original languageEnglish (US)
Pages (from-to)873-881
Number of pages9
JournalCurrent Opinion in Investigational Drugs
Volume7
Issue number10
StatePublished - Oct 2006

Fingerprint

Androgen Receptors
Androgens
Prostatic Neoplasms
Androgen Receptor Antagonists
Eunuchism
Anabolic Agents
Muscles
Dihydrotestosterone
Prostatic Hyperplasia
Molecular Structure
Osteoporosis
Testosterone
Anemia
Prostate
Steroids
Maintenance
Depression
Ligands
Bone and Bones
Wounds and Injuries

Keywords

  • Agonist
  • Anabolic
  • Androgen receptor
  • Androgenic
  • Antagonist
  • Testosterone

ASJC Scopus subject areas

  • Pharmacology

Cite this

Selective androgen receptor modulators : In pursuit of tissue-selective androgens. / Omwancha, Josephat; Brown, Terry R.

In: Current Opinion in Investigational Drugs, Vol. 7, No. 10, 10.2006, p. 873-881.

Research output: Contribution to journalArticle

Omwancha, Josephat ; Brown, Terry R. / Selective androgen receptor modulators : In pursuit of tissue-selective androgens. In: Current Opinion in Investigational Drugs. 2006 ; Vol. 7, No. 10. pp. 873-881.
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