Selective and Nonselective Monoamine Oxidase Inhibitors: Behavioral Disturbances During Their Administration to Depressed Patients

David Pickar, Dennis L. Murphy, Robert M. Cohen, Iain C. Campbell, Steven Lipper

Research output: Contribution to journalArticle

Abstract

The occurrence of behavioral disturbances during fourweek treatment of depressed patients with the nonselective monoamine oxidase (MAO) inhibitor, phenelzine sulfate (N = 14), the selective MAO-type A inhibitor, clorgyline (N = 12), and the partially selective MAO-type B inhibitor, pargyline hydrochloride (N = 13), was studied. Behavioral disturbances were encountered during treatment with each of the MAO-inhibiting drugs, with an overall incidence of 15% (six of 39 patients). All but one episode met criteria for mania or hypomania. Patients with bipolar illness experienced significantly greater incidences of behavioral disturbances in comparison with patients with unipolar illness (35.3% v 4.5%, respectively). The earliest latency to onset of a behavioral disturbance was 18 days, whereas the mean latencies were 22 to 26 days. Episodes of hypomania were observed after discontinuation of drug treatment in individual patients with unipolar and bipolar illness. Repeated MAO-inhibitor treatment, as part of a crossover study of clorgyline and pargyline, produced an increased severity of behavioral disturbances and a significantly shortened latency to onset.

Original languageEnglish (US)
Pages (from-to)535-540
Number of pages6
JournalArchives of General Psychiatry
Volume39
Issue number5
DOIs
StatePublished - 1982
Externally publishedYes

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Monoamine Oxidase Inhibitors
Clorgyline
Pargyline
Phenelzine
Incidence
Monoamine Oxidase
Therapeutics
Bipolar Disorder
Pharmaceutical Preparations
Cross-Over Studies
Latency
Illness

ASJC Scopus subject areas

  • Arts and Humanities (miscellaneous)
  • Psychiatry and Mental health

Cite this

Selective and Nonselective Monoamine Oxidase Inhibitors : Behavioral Disturbances During Their Administration to Depressed Patients. / Pickar, David; Murphy, Dennis L.; Cohen, Robert M.; Campbell, Iain C.; Lipper, Steven.

In: Archives of General Psychiatry, Vol. 39, No. 5, 1982, p. 535-540.

Research output: Contribution to journalArticle

Pickar, David ; Murphy, Dennis L. ; Cohen, Robert M. ; Campbell, Iain C. ; Lipper, Steven. / Selective and Nonselective Monoamine Oxidase Inhibitors : Behavioral Disturbances During Their Administration to Depressed Patients. In: Archives of General Psychiatry. 1982 ; Vol. 39, No. 5. pp. 535-540.
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