Selective activation of human mast cells by general anesthetics

C. Stellato; V. Casolaro; A. Ciccarelli; G. de Crescenzo; V. Patella; G. Marone

doi:10.1007/BF01997330

Selective activation of human mast cells by general anesthetics

C. Stellato, V. Casolaro, A. Ciccarelli, G. de Crescenzo, V. Patella, G. Marone

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Abstract

We investigated the in vitro effects of increasing concentrations of three general anesthetics commonly used in clinical practice, i.e., ketamine (10^-6-10^-3M), thiopentone (10^-5-8×10^-4M) and propofol (5-70 μg/ml), on histamine release (HR) from human peripheral blood basophils and mast cells isolated from lung parenchyma (HLMC) and skin tissues (HSMC). None of the drugs induced HR from basophils. Ketamine caused HR from HLMC (p

Original language	English (US)
Journal	Agents and Actions
Volume	36
Issue number	2 Supplement
DOIs	https://doi.org/10.1007/BF01997330
State	Published - Jun 1992
Externally published	Yes

ASJC Scopus subject areas

Toxicology
Pharmacology (medical)

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title = "Selective activation of human mast cells by general anesthetics",

abstract = "We investigated the in vitro effects of increasing concentrations of three general anesthetics commonly used in clinical practice, i.e., ketamine (10-6-10-3M), thiopentone (10-5-8×10-4M) and propofol (5-70 μg/ml), on histamine release (HR) from human peripheral blood basophils and mast cells isolated from lung parenchyma (HLMC) and skin tissues (HSMC). None of the drugs induced HR from basophils. Ketamine caused HR from HLMC (p",

author = "C. Stellato and V. Casolaro and A. Ciccarelli and {de Crescenzo}, G. and V. Patella and G. Marone",

year = "1992",

month = jun,

doi = "10.1007/BF01997330",

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volume = "36",

journal = "Agents and Actions",

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T1 - Selective activation of human mast cells by general anesthetics

AU - Stellato, C.

AU - Casolaro, V.

AU - Ciccarelli, A.

AU - de Crescenzo, G.

AU - Patella, V.

AU - Marone, G.

PY - 1992/6

Y1 - 1992/6

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AB - We investigated the in vitro effects of increasing concentrations of three general anesthetics commonly used in clinical practice, i.e., ketamine (10-6-10-3M), thiopentone (10-5-8×10-4M) and propofol (5-70 μg/ml), on histamine release (HR) from human peripheral blood basophils and mast cells isolated from lung parenchyma (HLMC) and skin tissues (HSMC). None of the drugs induced HR from basophils. Ketamine caused HR from HLMC (p

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SN - 0065-4299

VL - 36

JO - Agents and Actions

JF - Agents and Actions

IS - 2 Supplement

ER -

Selective activation of human mast cells by general anesthetics

Abstract

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