Selection of the appropriate parameter to measure neural regeneration

A. L. Dellon, S. E. Mackinnon

Research output: Contribution to journalArticlepeer-review

Abstract

A rat sciatic nerve model of regeneration was assessed by multiple techniques to determine the relationship between parameters of neural regeneration in common use today. The results demonstrated significant correlation and internal consistency between electrophysiological and morphological parameters (i.e., conduction velocity and fiber diameter) but not necessarily a correlation between these physiological parameters and overall nerve function as assessed by a modified walking track technique. Guidelines for parameter selection are suggested based upon the specific question being investigated (e.g., sensory and/or motor function versus axoplasmic flow and/or motor function versus axoplasmiv flow and/or neurotropism) rather than the nonspecific 'neural regeneration.'

Original languageEnglish (US)
Pages (from-to)197-202
Number of pages6
JournalAnnals of plastic surgery
Volume23
Issue number3
DOIs
StatePublished - 1989

ASJC Scopus subject areas

  • Surgery

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