TY - JOUR
T1 - Selection of resistant mutants of Mycobacterium avium in beige mice by clarithromycin monotherapy
AU - Ji, B.
AU - Lounis, N.
AU - Truffot-Pernot, C.
AU - Grosset, J.
PY - 1992
Y1 - 1992
N2 - Beige mice were inoculated intravenously with 107.90 CFU of Mycobacterium avium 101. Among the untreated control mice, when the mean CFU per spleen increased to a level greater than 108, small numbers of organisms resistant to clarithromycin (CLARI) were isolated from some of the spleens; the frequency of CLARI-resistant mutants was estimated to be between 10-8 and 10-9. In mice treated with 200 mg of CLARI per kg of body weight six times weekly, however, CLARI-resistant organisms were isolated from the spleens of all mice examined after treatment for 8 weeks; the mean CFU per spleen and the frequency of resistant mutants were significantly greater than those of control mice and increased further after treatment for 16 weeks. The MICs of CLARI against the resistant organisms isolated from both control and treated mice were ≥512 μg/ml.
AB - Beige mice were inoculated intravenously with 107.90 CFU of Mycobacterium avium 101. Among the untreated control mice, when the mean CFU per spleen increased to a level greater than 108, small numbers of organisms resistant to clarithromycin (CLARI) were isolated from some of the spleens; the frequency of CLARI-resistant mutants was estimated to be between 10-8 and 10-9. In mice treated with 200 mg of CLARI per kg of body weight six times weekly, however, CLARI-resistant organisms were isolated from the spleens of all mice examined after treatment for 8 weeks; the mean CFU per spleen and the frequency of resistant mutants were significantly greater than those of control mice and increased further after treatment for 16 weeks. The MICs of CLARI against the resistant organisms isolated from both control and treated mice were ≥512 μg/ml.
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U2 - 10.1128/AAC.36.12.2839
DO - 10.1128/AAC.36.12.2839
M3 - Comment/debate
C2 - 1482155
AN - SCOPUS:0026491064
SN - 0066-4804
VL - 36
SP - 2839
EP - 2840
JO - Antimicrobial agents and chemotherapy
JF - Antimicrobial agents and chemotherapy
IS - 12
ER -