Abstract
MHC II proteins present processed antigens to CD4 + T cells through a complex set of events and players that include chaperons and accessory molecules. Antigen processing machinery is optimized for the selection of the best fitting peptides, called ‘immunodominant epitopes’ in the MHC II groove to which, specific CD4 + T cells respond and differentiate into memory T cells. However, due to the complexity of antigen processing, understanding the parameters that lead to immunodominance has proved difficult. Moreover, immunodominance of epitopes vary, depending on multiple factors that include; simultaneous processing of multiple proteins, involvement of multiple alleles of MHC II that can bind to the same antigen, or competition among several suitable epitopes on a single protein antigen. The current dogma assumes that once an antigenic determinant is selected under a specific condition, it would emerge immunodominant wherever it is placed. Here we will discuss some established parameters that contribute to immunodominance as well as some new findings, which demonstrate that slight changes to antigen structure can cause a complete shift in epitope selection during antigen processing and distort the natural immunodominant epitope.
| Original language | English (US) |
|---|---|
| Journal | Molecular Immunology |
| DOIs | |
| State | Accepted/In press - Jan 1 2018 |
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Keywords
- Cathepsins
- Cell free antigen processing
- Epitope hierarchy
- HLA-DR
- Immunodominance
- Structural constraints
ASJC Scopus subject areas
- Immunology
- Molecular Biology
Cite this
Selection of immunodominant epitopes during antigen processing is hierarchical. / Sadegh-Nasseri, Scheheraza; Kim, Ae Ryon.
In: Molecular Immunology, 01.01.2018.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Selection of immunodominant epitopes during antigen processing is hierarchical
AU - Sadegh-Nasseri, Scheheraza
AU - Kim, Ae Ryon
PY - 2018/1/1
Y1 - 2018/1/1
N2 - MHC II proteins present processed antigens to CD4 + T cells through a complex set of events and players that include chaperons and accessory molecules. Antigen processing machinery is optimized for the selection of the best fitting peptides, called ‘immunodominant epitopes’ in the MHC II groove to which, specific CD4 + T cells respond and differentiate into memory T cells. However, due to the complexity of antigen processing, understanding the parameters that lead to immunodominance has proved difficult. Moreover, immunodominance of epitopes vary, depending on multiple factors that include; simultaneous processing of multiple proteins, involvement of multiple alleles of MHC II that can bind to the same antigen, or competition among several suitable epitopes on a single protein antigen. The current dogma assumes that once an antigenic determinant is selected under a specific condition, it would emerge immunodominant wherever it is placed. Here we will discuss some established parameters that contribute to immunodominance as well as some new findings, which demonstrate that slight changes to antigen structure can cause a complete shift in epitope selection during antigen processing and distort the natural immunodominant epitope.
AB - MHC II proteins present processed antigens to CD4 + T cells through a complex set of events and players that include chaperons and accessory molecules. Antigen processing machinery is optimized for the selection of the best fitting peptides, called ‘immunodominant epitopes’ in the MHC II groove to which, specific CD4 + T cells respond and differentiate into memory T cells. However, due to the complexity of antigen processing, understanding the parameters that lead to immunodominance has proved difficult. Moreover, immunodominance of epitopes vary, depending on multiple factors that include; simultaneous processing of multiple proteins, involvement of multiple alleles of MHC II that can bind to the same antigen, or competition among several suitable epitopes on a single protein antigen. The current dogma assumes that once an antigenic determinant is selected under a specific condition, it would emerge immunodominant wherever it is placed. Here we will discuss some established parameters that contribute to immunodominance as well as some new findings, which demonstrate that slight changes to antigen structure can cause a complete shift in epitope selection during antigen processing and distort the natural immunodominant epitope.
KW - Cathepsins
KW - Cell free antigen processing
KW - Epitope hierarchy
KW - HLA-DR
KW - Immunodominance
KW - Structural constraints
UR - http://www.scopus.com/inward/record.url?scp=85052069833&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85052069833&partnerID=8YFLogxK
U2 - 10.1016/j.molimm.2018.08.011
DO - 10.1016/j.molimm.2018.08.011
M3 - Article
C2 - 30146122
AN - SCOPUS:85052069833
JO - Molecular Immunology
JF - Molecular Immunology
SN - 0161-5890
ER -