Selecting the best haploidentical donor

Shannon R. McCurdy, Ephraim J Fuchs

Research output: Contribution to journalReview article

Abstract

The substantial evidence of the safety of human leukocyte antigen (HLA)-haploidentical (haplo) blood or marrow transplantation (BMT) has led to its increasing utilization. When prioritizing HLA-matched grafts, patients frequently have few or no donors from whom to choose. However, a given patient may have multiple suitable haplo donors. Therefore factors other than HLA-match become critical for selecting the best donor. We recommend a donor selection algorithm based on the donor-specific antibodies, ABO match, donor age, donor sex, and cytomegalovirus (CMV) serostatus match. Despite provocative initial evidence, further studies are warranted to determine whether there is any benefit to selecting a haplo donor based on the number of HLA-mismatches, natural killer cell alloreactivity, or the presence of non-inherited maternal HLA antigens.

Original languageEnglish (US)
Pages (from-to)246-251
Number of pages6
JournalSeminars in Hematology
Volume53
Issue number4
DOIs
StatePublished - Oct 1 2016

Keywords

  • Donor Selection
  • Haploidentical
  • Post-transplant cyclophosphamide

ASJC Scopus subject areas

  • Hematology

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