Seizures and schizophrenia

Research output: Contribution to journalReview article

Abstract

Patients with epilepsy develop psychosis or schizophrenia at a rate exceeding that expected if the two disorders were independent. Similarly, patients with schizophrenia are more prone to seizures than the general population. This excess vulnerability may be conferred by the neuropathological substrate of schizophrenia itself or by the secondary effects of the illness, including exposure to psychotropic medications that lower the seizure threshold. Neuropathological investigations into the anatomic substrate of seizures in patients with psychosis or schizophrenia are consistent with the notion that there are neurodevelopmental abnormalities involving the mesial temporal lobe. Finally, clinical recommendations for the evaluation and pharmacological management of patients with schizophrenia who have one or more seizures are described.

Original languageEnglish (US)
Pages (from-to)611-622
Number of pages12
JournalSchizophrenia Bulletin
Volume23
Issue number4
StatePublished - 1997
Externally publishedYes

Fingerprint

Schizophrenia
Seizures
Psychotic Disorders
Temporal Lobe
Epilepsy
Pharmacology
Population

ASJC Scopus subject areas

  • Psychiatry and Mental health

Cite this

Seizures and schizophrenia. / Hyde, Thomas; Weinberger, Daniel.

In: Schizophrenia Bulletin, Vol. 23, No. 4, 1997, p. 611-622.

Research output: Contribution to journalReview article

@article{e52d8ae8c8a8442fa63ad7e6ba1d9bab,
title = "Seizures and schizophrenia",
abstract = "Patients with epilepsy develop psychosis or schizophrenia at a rate exceeding that expected if the two disorders were independent. Similarly, patients with schizophrenia are more prone to seizures than the general population. This excess vulnerability may be conferred by the neuropathological substrate of schizophrenia itself or by the secondary effects of the illness, including exposure to psychotropic medications that lower the seizure threshold. Neuropathological investigations into the anatomic substrate of seizures in patients with psychosis or schizophrenia are consistent with the notion that there are neurodevelopmental abnormalities involving the mesial temporal lobe. Finally, clinical recommendations for the evaluation and pharmacological management of patients with schizophrenia who have one or more seizures are described.",
author = "Thomas Hyde and Daniel Weinberger",
year = "1997",
language = "English (US)",
volume = "23",
pages = "611--622",
journal = "Schizophrenia Bulletin",
issn = "0586-7614",
publisher = "Oxford University Press",
number = "4",

}

TY - JOUR

T1 - Seizures and schizophrenia

AU - Hyde, Thomas

AU - Weinberger, Daniel

PY - 1997

Y1 - 1997

N2 - Patients with epilepsy develop psychosis or schizophrenia at a rate exceeding that expected if the two disorders were independent. Similarly, patients with schizophrenia are more prone to seizures than the general population. This excess vulnerability may be conferred by the neuropathological substrate of schizophrenia itself or by the secondary effects of the illness, including exposure to psychotropic medications that lower the seizure threshold. Neuropathological investigations into the anatomic substrate of seizures in patients with psychosis or schizophrenia are consistent with the notion that there are neurodevelopmental abnormalities involving the mesial temporal lobe. Finally, clinical recommendations for the evaluation and pharmacological management of patients with schizophrenia who have one or more seizures are described.

AB - Patients with epilepsy develop psychosis or schizophrenia at a rate exceeding that expected if the two disorders were independent. Similarly, patients with schizophrenia are more prone to seizures than the general population. This excess vulnerability may be conferred by the neuropathological substrate of schizophrenia itself or by the secondary effects of the illness, including exposure to psychotropic medications that lower the seizure threshold. Neuropathological investigations into the anatomic substrate of seizures in patients with psychosis or schizophrenia are consistent with the notion that there are neurodevelopmental abnormalities involving the mesial temporal lobe. Finally, clinical recommendations for the evaluation and pharmacological management of patients with schizophrenia who have one or more seizures are described.

UR - http://www.scopus.com/inward/record.url?scp=0030707538&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0030707538&partnerID=8YFLogxK

M3 - Review article

C2 - 9365998

AN - SCOPUS:0030707538

VL - 23

SP - 611

EP - 622

JO - Schizophrenia Bulletin

JF - Schizophrenia Bulletin

SN - 0586-7614

IS - 4

ER -