Seizure semiology: An overview of the 'inverse problem'

Andrea O. Rossetti, Peter W. Kaplan

Research output: Contribution to journalReview articlepeer-review

33 Scopus citations


In clinical practice, a classification of seizures based on clinical signs and symptoms leads to an improved understanding of epilepsy-related issues and therefore strongly contributes to a better patient care. The inverse problem involves inferring the anatomical brain localization of a seizure from the scalp surface EEG, a concept we apply here to correlate seizure origin with seizure semiology. The spheres of sensorium, motor features, consciousness changes and autonomic alterations during ictal and postictal manifestations are reviewed, including several subdivisions used to better categorize particular features. Particular attention is given to behavioral features, as well as to features occurring in idiopathic generalized epileptic syndromes and psychogenic nonepileptic spells.

Original languageEnglish (US)
Pages (from-to)3-10
Number of pages8
JournalEuropean Neurology
Issue number1
StatePublished - Jan 2010


  • Epilepsy
  • Focal seizures
  • Ictal manifestations
  • Lateralization
  • Localization
  • Postictal manifestations

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology


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