Seizure-induced glutamate release in mature and immature animals: An in vivo microdialysis study

Zhao Liu, Carl E. Stafstrom, Matthew R. Sarkisian, Yili Yang, Ariyuki Hori, Pushpa Tandon, Gregory L. Holmes

Research output: Contribution to journalArticle

Abstract

A glutamate biosensor was used to measure extracellular glutamate concentrations in the hippocampus of mature and immature animals. Significant elevations of extracellular glutamate were observed following seizures induced by either kainic acid or pilocarpine. The degree of glutamate increase following seizures was similar in both mature and immature animals. These results suggest that excitotoxicity may play a role in seizure-induced brain damage in the adult brain. In the immature brain, however, no brain damage is seen after seizures, suggesting that glutamate release may not cause as significant excitotoxic damage early in development.

Original languageEnglish (US)
Pages (from-to)2019-2023
Number of pages5
JournalNeuroreport
Volume8
Issue number8
DOIs
StatePublished - 1997
Externally publishedYes

Keywords

  • Excitotoxicity
  • Glutamate
  • Glutamate biosensor
  • Immature brain
  • Kainic acid
  • Pilocarpine
  • Seizures

ASJC Scopus subject areas

  • Neuroscience(all)

Fingerprint Dive into the research topics of 'Seizure-induced glutamate release in mature and immature animals: An in vivo microdialysis study'. Together they form a unique fingerprint.

  • Cite this