Seizure disorders in systemic lupus erythematosus results from an international, prospective, inception cohort study

John G. Hanly, Murray B. Urowitz, Li Su, Caroline Gordon, Sang Cheol Bae, Jorge Sanchez-Guerrero, Juanita Romero-Diaz, Daniel J. Wallace, Ann E. Clarke, E. M. Ginzler, Joan T. Merrill, David A. Isenberg, Anisur Rahman, Michelle Petri, Paul R. Fortin, D. D. Gladman, Ian N. Bruce, Kristjan Steinsson, M. A. Dooley, Munther A. Khamashta & 20 others Graciela S. Alarcón, Barri J. Fessler, Rosalind Ramsey-Goldman, Susan Manzi, Asad A. Zoma, Gunnar K. Sturfelt, Ola Nived, Cynthia Aranow, Meggan Mackay, Manuel Ramos-Casals, R. F. Van Vollenhoven, Kenneth C. Kalunian, Guillermo Ruiz-Irastorza, Sam Lim, Diane L. Kamen, Christine A. Peschken, Murat Inanc, Chris Theriault, Kara Thompson, Vernon Farewell

Research output: Contribution to journalArticle

Abstract

Objective: The aim of this study was to describe the frequency, attribution, outcome and predictors of seizures in systemic lupus erythematosus (SLE). Methods: The Systemic Lupus International Collaborating Clinics, or SLICC, performed a prospective inception cohort study. Demographic variables, global SLE disease activity (SLE Disease Activity Index 2000), cumulative organ damage (SLICC/American College of Rheumatology Damage Index (SDI)) and neuropsychiatric events were recorded at enrolment and annually. Lupus anticoagulant, anticardiolipin, anti-β 2glycoprotein-I, antiribosomal P and anti-NR2 glutamate receptor antibodies were measured at enrolment. Physician outcomes of seizures were recorded. Patient outcomes were derived from the SF-36 (36-Item Short Form Health Survey) mental component summary and physical component summary scores. Statistical analyses included Cox and linear regressions. Results: The cohort was 89.4% female with a mean follow-up of 3.5±2.9 years. Of 1631 patients, 75 (4.6%) had ≥1 seizure, the majority around the time of SLE diagnosis. Multivariate analysis indicated a higher risk of seizures with African race/ethnicity (HR (CI): 1.97 (1.07 to 3.63); p=0.03) and lower education status (1.97 (1.21 to 3.19); p

Original languageEnglish (US)
Pages (from-to)1502-1509
Number of pages8
JournalAnnals of the Rheumatic Diseases
Volume71
Issue number9
DOIs
StatePublished - Sep 2012

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Systemic Lupus Erythematosus
Epilepsy
Seizures
Cohort Studies
Lupus Coagulation Inhibitor
Glutamate Receptors
Linear regression
Education
Antibodies
Health Surveys
Linear Models
Multivariate Analysis
Demography
Physicians

ASJC Scopus subject areas

  • Rheumatology
  • Immunology
  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Allergy

Cite this

Hanly, J. G., Urowitz, M. B., Su, L., Gordon, C., Bae, S. C., Sanchez-Guerrero, J., ... Farewell, V. (2012). Seizure disorders in systemic lupus erythematosus results from an international, prospective, inception cohort study. Annals of the Rheumatic Diseases, 71(9), 1502-1509. https://doi.org/10.1136/annrheumdis-2011-201089

Seizure disorders in systemic lupus erythematosus results from an international, prospective, inception cohort study. / Hanly, John G.; Urowitz, Murray B.; Su, Li; Gordon, Caroline; Bae, Sang Cheol; Sanchez-Guerrero, Jorge; Romero-Diaz, Juanita; Wallace, Daniel J.; Clarke, Ann E.; Ginzler, E. M.; Merrill, Joan T.; Isenberg, David A.; Rahman, Anisur; Petri, Michelle; Fortin, Paul R.; Gladman, D. D.; Bruce, Ian N.; Steinsson, Kristjan; Dooley, M. A.; Khamashta, Munther A.; Alarcón, Graciela S.; Fessler, Barri J.; Ramsey-Goldman, Rosalind; Manzi, Susan; Zoma, Asad A.; Sturfelt, Gunnar K.; Nived, Ola; Aranow, Cynthia; Mackay, Meggan; Ramos-Casals, Manuel; Van Vollenhoven, R. F.; Kalunian, Kenneth C.; Ruiz-Irastorza, Guillermo; Lim, Sam; Kamen, Diane L.; Peschken, Christine A.; Inanc, Murat; Theriault, Chris; Thompson, Kara; Farewell, Vernon.

In: Annals of the Rheumatic Diseases, Vol. 71, No. 9, 09.2012, p. 1502-1509.

Research output: Contribution to journalArticle

Hanly, JG, Urowitz, MB, Su, L, Gordon, C, Bae, SC, Sanchez-Guerrero, J, Romero-Diaz, J, Wallace, DJ, Clarke, AE, Ginzler, EM, Merrill, JT, Isenberg, DA, Rahman, A, Petri, M, Fortin, PR, Gladman, DD, Bruce, IN, Steinsson, K, Dooley, MA, Khamashta, MA, Alarcón, GS, Fessler, BJ, Ramsey-Goldman, R, Manzi, S, Zoma, AA, Sturfelt, GK, Nived, O, Aranow, C, Mackay, M, Ramos-Casals, M, Van Vollenhoven, RF, Kalunian, KC, Ruiz-Irastorza, G, Lim, S, Kamen, DL, Peschken, CA, Inanc, M, Theriault, C, Thompson, K & Farewell, V 2012, 'Seizure disorders in systemic lupus erythematosus results from an international, prospective, inception cohort study', Annals of the Rheumatic Diseases, vol. 71, no. 9, pp. 1502-1509. https://doi.org/10.1136/annrheumdis-2011-201089
Hanly, John G. ; Urowitz, Murray B. ; Su, Li ; Gordon, Caroline ; Bae, Sang Cheol ; Sanchez-Guerrero, Jorge ; Romero-Diaz, Juanita ; Wallace, Daniel J. ; Clarke, Ann E. ; Ginzler, E. M. ; Merrill, Joan T. ; Isenberg, David A. ; Rahman, Anisur ; Petri, Michelle ; Fortin, Paul R. ; Gladman, D. D. ; Bruce, Ian N. ; Steinsson, Kristjan ; Dooley, M. A. ; Khamashta, Munther A. ; Alarcón, Graciela S. ; Fessler, Barri J. ; Ramsey-Goldman, Rosalind ; Manzi, Susan ; Zoma, Asad A. ; Sturfelt, Gunnar K. ; Nived, Ola ; Aranow, Cynthia ; Mackay, Meggan ; Ramos-Casals, Manuel ; Van Vollenhoven, R. F. ; Kalunian, Kenneth C. ; Ruiz-Irastorza, Guillermo ; Lim, Sam ; Kamen, Diane L. ; Peschken, Christine A. ; Inanc, Murat ; Theriault, Chris ; Thompson, Kara ; Farewell, Vernon. / Seizure disorders in systemic lupus erythematosus results from an international, prospective, inception cohort study. In: Annals of the Rheumatic Diseases. 2012 ; Vol. 71, No. 9. pp. 1502-1509.
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abstract = "Objective: The aim of this study was to describe the frequency, attribution, outcome and predictors of seizures in systemic lupus erythematosus (SLE). Methods: The Systemic Lupus International Collaborating Clinics, or SLICC, performed a prospective inception cohort study. Demographic variables, global SLE disease activity (SLE Disease Activity Index 2000), cumulative organ damage (SLICC/American College of Rheumatology Damage Index (SDI)) and neuropsychiatric events were recorded at enrolment and annually. Lupus anticoagulant, anticardiolipin, anti-β 2glycoprotein-I, antiribosomal P and anti-NR2 glutamate receptor antibodies were measured at enrolment. Physician outcomes of seizures were recorded. Patient outcomes were derived from the SF-36 (36-Item Short Form Health Survey) mental component summary and physical component summary scores. Statistical analyses included Cox and linear regressions. Results: The cohort was 89.4{\%} female with a mean follow-up of 3.5±2.9 years. Of 1631 patients, 75 (4.6{\%}) had ≥1 seizure, the majority around the time of SLE diagnosis. Multivariate analysis indicated a higher risk of seizures with African race/ethnicity (HR (CI): 1.97 (1.07 to 3.63); p=0.03) and lower education status (1.97 (1.21 to 3.19); p",
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T1 - Seizure disorders in systemic lupus erythematosus results from an international, prospective, inception cohort study

AU - Hanly, John G.

AU - Urowitz, Murray B.

AU - Su, Li

AU - Gordon, Caroline

AU - Bae, Sang Cheol

AU - Sanchez-Guerrero, Jorge

AU - Romero-Diaz, Juanita

AU - Wallace, Daniel J.

AU - Clarke, Ann E.

AU - Ginzler, E. M.

AU - Merrill, Joan T.

AU - Isenberg, David A.

AU - Rahman, Anisur

AU - Petri, Michelle

AU - Fortin, Paul R.

AU - Gladman, D. D.

AU - Bruce, Ian N.

AU - Steinsson, Kristjan

AU - Dooley, M. A.

AU - Khamashta, Munther A.

AU - Alarcón, Graciela S.

AU - Fessler, Barri J.

AU - Ramsey-Goldman, Rosalind

AU - Manzi, Susan

AU - Zoma, Asad A.

AU - Sturfelt, Gunnar K.

AU - Nived, Ola

AU - Aranow, Cynthia

AU - Mackay, Meggan

AU - Ramos-Casals, Manuel

AU - Van Vollenhoven, R. F.

AU - Kalunian, Kenneth C.

AU - Ruiz-Irastorza, Guillermo

AU - Lim, Sam

AU - Kamen, Diane L.

AU - Peschken, Christine A.

AU - Inanc, Murat

AU - Theriault, Chris

AU - Thompson, Kara

AU - Farewell, Vernon

PY - 2012/9

Y1 - 2012/9

N2 - Objective: The aim of this study was to describe the frequency, attribution, outcome and predictors of seizures in systemic lupus erythematosus (SLE). Methods: The Systemic Lupus International Collaborating Clinics, or SLICC, performed a prospective inception cohort study. Demographic variables, global SLE disease activity (SLE Disease Activity Index 2000), cumulative organ damage (SLICC/American College of Rheumatology Damage Index (SDI)) and neuropsychiatric events were recorded at enrolment and annually. Lupus anticoagulant, anticardiolipin, anti-β 2glycoprotein-I, antiribosomal P and anti-NR2 glutamate receptor antibodies were measured at enrolment. Physician outcomes of seizures were recorded. Patient outcomes were derived from the SF-36 (36-Item Short Form Health Survey) mental component summary and physical component summary scores. Statistical analyses included Cox and linear regressions. Results: The cohort was 89.4% female with a mean follow-up of 3.5±2.9 years. Of 1631 patients, 75 (4.6%) had ≥1 seizure, the majority around the time of SLE diagnosis. Multivariate analysis indicated a higher risk of seizures with African race/ethnicity (HR (CI): 1.97 (1.07 to 3.63); p=0.03) and lower education status (1.97 (1.21 to 3.19); p

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