Segregation analysis of waist circumference, hip circumference and waist-to-hip ratio in the Korean Nationwide Family Study

S. H. Jee, M. T. Kim, S. Y. Lee, Terri L Beaty

Research output: Contribution to journalArticle

Abstract

AIM: A central distribution of adipose tissue is frequently associated with cardiovascular disease and its risk factors. In this study, we investigated environmental, familial and genetic influences on waist circumference (WC), hip circumference (HC) and waist-to-hip ratio (WHR) in 2507 members of 435 families who had participated in the Korean Nationwide Health Examination Survey. METHOD: Maximum likelihood methods were used to fit several genetic and nongenetic models of inheritance to these data to determine whether an unobserved Mendelian major gene could explain the familial distribution of WC, HC and WHR. Adjustments for age, age2, body mass index, smoking, alcohol consumption and exercise were carried out separately for males and females by multiple regression procedures for WC, HC and WHR phenotypes prior to segregation analysis. Regression models were used to test genetic and non-genetic models in these 435 families. RESULTS: Segregation analysis did not provide statistical evidence of a major gene controlling either HC or WHR. Mendelian single-locus models with two underlying genotypic distributions were best supported by these data on WC, and this putative major gene explained the 22.4% of variance in adjusted WC. CONCLUSION: Future linkage studies may be worthwhile to further clarify the mechanisms controlling WC.

Original languageEnglish (US)
Pages (from-to)228-233
Number of pages6
JournalInternational Journal of Obesity
Volume26
Issue number2
DOIs
StatePublished - Jan 1 2002

Fingerprint

Waist-Hip Ratio
Waist Circumference
Hip
Genes
Genetic Models
Health Surveys
Alcohol Drinking
Adipose Tissue
Body Mass Index
Cardiovascular Diseases
Smoking
Phenotype

Keywords

  • Hip
  • Segregation analysis
  • Waist
  • Waist-to-hip ratio

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Segregation analysis of waist circumference, hip circumference and waist-to-hip ratio in the Korean Nationwide Family Study. / Jee, S. H.; Kim, M. T.; Lee, S. Y.; Beaty, Terri L.

In: International Journal of Obesity, Vol. 26, No. 2, 01.01.2002, p. 228-233.

Research output: Contribution to journalArticle

@article{74f849088b244fd3855bb949b36b344a,
title = "Segregation analysis of waist circumference, hip circumference and waist-to-hip ratio in the Korean Nationwide Family Study",
abstract = "AIM: A central distribution of adipose tissue is frequently associated with cardiovascular disease and its risk factors. In this study, we investigated environmental, familial and genetic influences on waist circumference (WC), hip circumference (HC) and waist-to-hip ratio (WHR) in 2507 members of 435 families who had participated in the Korean Nationwide Health Examination Survey. METHOD: Maximum likelihood methods were used to fit several genetic and nongenetic models of inheritance to these data to determine whether an unobserved Mendelian major gene could explain the familial distribution of WC, HC and WHR. Adjustments for age, age2, body mass index, smoking, alcohol consumption and exercise were carried out separately for males and females by multiple regression procedures for WC, HC and WHR phenotypes prior to segregation analysis. Regression models were used to test genetic and non-genetic models in these 435 families. RESULTS: Segregation analysis did not provide statistical evidence of a major gene controlling either HC or WHR. Mendelian single-locus models with two underlying genotypic distributions were best supported by these data on WC, and this putative major gene explained the 22.4{\%} of variance in adjusted WC. CONCLUSION: Future linkage studies may be worthwhile to further clarify the mechanisms controlling WC.",
keywords = "Hip, Segregation analysis, Waist, Waist-to-hip ratio",
author = "Jee, {S. H.} and Kim, {M. T.} and Lee, {S. Y.} and Beaty, {Terri L}",
year = "2002",
month = "1",
day = "1",
doi = "10.1038/sj.ijo.0801884",
language = "English (US)",
volume = "26",
pages = "228--233",
journal = "International Journal of Obesity",
issn = "0307-0565",
publisher = "Nature Publishing Group",
number = "2",

}

TY - JOUR

T1 - Segregation analysis of waist circumference, hip circumference and waist-to-hip ratio in the Korean Nationwide Family Study

AU - Jee, S. H.

AU - Kim, M. T.

AU - Lee, S. Y.

AU - Beaty, Terri L

PY - 2002/1/1

Y1 - 2002/1/1

N2 - AIM: A central distribution of adipose tissue is frequently associated with cardiovascular disease and its risk factors. In this study, we investigated environmental, familial and genetic influences on waist circumference (WC), hip circumference (HC) and waist-to-hip ratio (WHR) in 2507 members of 435 families who had participated in the Korean Nationwide Health Examination Survey. METHOD: Maximum likelihood methods were used to fit several genetic and nongenetic models of inheritance to these data to determine whether an unobserved Mendelian major gene could explain the familial distribution of WC, HC and WHR. Adjustments for age, age2, body mass index, smoking, alcohol consumption and exercise were carried out separately for males and females by multiple regression procedures for WC, HC and WHR phenotypes prior to segregation analysis. Regression models were used to test genetic and non-genetic models in these 435 families. RESULTS: Segregation analysis did not provide statistical evidence of a major gene controlling either HC or WHR. Mendelian single-locus models with two underlying genotypic distributions were best supported by these data on WC, and this putative major gene explained the 22.4% of variance in adjusted WC. CONCLUSION: Future linkage studies may be worthwhile to further clarify the mechanisms controlling WC.

AB - AIM: A central distribution of adipose tissue is frequently associated with cardiovascular disease and its risk factors. In this study, we investigated environmental, familial and genetic influences on waist circumference (WC), hip circumference (HC) and waist-to-hip ratio (WHR) in 2507 members of 435 families who had participated in the Korean Nationwide Health Examination Survey. METHOD: Maximum likelihood methods were used to fit several genetic and nongenetic models of inheritance to these data to determine whether an unobserved Mendelian major gene could explain the familial distribution of WC, HC and WHR. Adjustments for age, age2, body mass index, smoking, alcohol consumption and exercise were carried out separately for males and females by multiple regression procedures for WC, HC and WHR phenotypes prior to segregation analysis. Regression models were used to test genetic and non-genetic models in these 435 families. RESULTS: Segregation analysis did not provide statistical evidence of a major gene controlling either HC or WHR. Mendelian single-locus models with two underlying genotypic distributions were best supported by these data on WC, and this putative major gene explained the 22.4% of variance in adjusted WC. CONCLUSION: Future linkage studies may be worthwhile to further clarify the mechanisms controlling WC.

KW - Hip

KW - Segregation analysis

KW - Waist

KW - Waist-to-hip ratio

UR - http://www.scopus.com/inward/record.url?scp=85047696051&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85047696051&partnerID=8YFLogxK

U2 - 10.1038/sj.ijo.0801884

DO - 10.1038/sj.ijo.0801884

M3 - Article

C2 - 11850755

AN - SCOPUS:85047696051

VL - 26

SP - 228

EP - 233

JO - International Journal of Obesity

JF - International Journal of Obesity

SN - 0307-0565

IS - 2

ER -