Segregation analysis of leprosy in families of northern Thailand

Diane K. Wagener, Victoria Schauf, Kenrad E. Nelson, David Scollard, Arthur Brown, Trevor Smith, Ingrid B. Borecki

Research output: Contribution to journalArticlepeer-review

Abstract

Sixty‐three families with multiple instances of leprosy were identified through a major leprosy treatment center in northern Thailand. Complex segregation analyses for single major genes or polygenic inheritance were performed using the maximum‐likelihood routine POINTER to determine the most likely etiologic model of genetic susceptibility. Liability differences between men and women were considered in these models. When individuals were considered to be affected because they had any form of leprosy, a generalized major gene model with nearly dominant parameters on the liability scale, but additive penetrances, was found to be the most likely. When only those individuals who had tuberculoid forms of leprosy were considered to be affected, a recessive model was found to be the most likely; however, the discrimination between various models was poor. Further analyses are necessary to delineate genetic mechanisms to explain these apparently divergent results. In particular, methods of testing two locus models should be considered.

Original languageEnglish (US)
Pages (from-to)95-105
Number of pages11
JournalGenetic epidemiology
Volume5
Issue number2
DOIs
StatePublished - 1988

Keywords

  • Thailand
  • etiologic model
  • tuberculoid leprosy

ASJC Scopus subject areas

  • Epidemiology
  • Genetics(clinical)

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