Segregation analysis of HDL3-C levels in families of patients undergoing coronary arteriography at an early age

Josef Coresh, Terri L Beaty, V. L. Prenger, J. Xu, P. O. Kwiterovich

Research output: Contribution to journalArticle

Abstract

HDL cholesterol (HDL-C) level is a risk factor for corollary heart disease. Studies have shown a strong genetic influence on HDL-C levels in addition to environmental influences, but no definite major gene control has been demonstrated. Since HDL subfractions may better reflect the actions of distinct metabolic alterations than total HDL, we tested the hypothesis that the amount of cholesterol in the denser HDL3 subfraction (HDL3-C) is under the control of a major gone. The study population included 676 family members of 116 probands who underwent coronary arteriography at an early age (men ≤50 and women ≤60 years). HDL3-C level was measured by using enzymatic methods after preparative ultracentrifugation at a density of 1.125 g/mL. HDL3-C was adjusted for age, gender, alcohol consumption, and smoking, which combined accounted for 3% of its variance. Segregation analysis was conducted on adjusted HDL3-C by using regressive models. The familial correlations for HDL3-C levels were spouse .03±.08, parent-offspring .14±.05, and sibling .24±.05. The data strongly supported a codominant mendelian model, with the common allele coding for lower HDL3-C levels and the rarer allele (frequency, 25%) coding for higher HDL3-C levels. This major gent explained 34% of the variation in HDL3-C levels and 9% of the variation in total HDL- C levels. These results suggest that HDL3-C levels exhibit clearer genetic control than total HDL-C and may therefore be a useful target for further genetic studies.

Original languageEnglish (US)
Pages (from-to)1307-1313
Number of pages7
JournalArteriosclerosis, Thrombosis, and Vascular Biology
Volume15
Issue number9
StatePublished - 1995

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HDL Cholesterol
Angiography
Ultracentrifugation
Spouses
Gene Frequency
Alcohol Drinking
Siblings
Heart Diseases
Smoking
Alleles
Cholesterol
Population
Genes

Keywords

  • HDL
  • HDL
  • major gene
  • population genetics
  • segregation analysis

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Segregation analysis of HDL3-C levels in families of patients undergoing coronary arteriography at an early age. / Coresh, Josef; Beaty, Terri L; Prenger, V. L.; Xu, J.; Kwiterovich, P. O.

In: Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 15, No. 9, 1995, p. 1307-1313.

Research output: Contribution to journalArticle

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