Segmented surface coil resonator for in vivo EPR applications at 1.1 GHz

Sergey Petryakov, Alexandre Samouilov, Michael Chzhan-Roytenberg, Eric Kesselring, Ziqi Sun, Jay L. Zweier

Research output: Contribution to journalArticle

Abstract

A four-loop segmented surface coil resonator (SSCR) with electronic frequency and coupling adjustments was constructed with 18 mm aperture and loading capability suitable for in vivo Electron Paramagnetic Resonance (EPR) spectroscopy and imaging applications at L-band. Increased sample volume and loading capability were achieved by employing a multi-loop three-dimensional surface coil structure. Symmetrical design of the resonator with coupling to each loop resulted in high homogeneity of RF magnetic field. Parallel loops were coupled to the feeder cable via balancing circuitry containing varactor diodes for electronic coupling and tuning over a wide range of loading conditions. Manually adjusted high Q trimmer capacitors were used for initial tuning with subsequent tuning electronically controlled using varactor diodes. This design provides transparency and homogeneity of magnetic field modulation in the sample volume, while matching components are shielded to minimize interference with modulation and ambient RF fields. It can accommodate lossy samples up to 90% of its aperture with high homogeneity of RF and modulation magnetic fields and can function as a surface loop or a slice volume resonator. Along with an outer coaxial NMR surface coil, the SSCR enabled EPR/NMR co-imaging of paramagnetic probes in living rats to a depth of 20 mm.

Original languageEnglish (US)
Pages (from-to)8-14
Number of pages7
JournalJournal of Magnetic Resonance
Volume198
Issue number1
DOIs
StatePublished - May 2009
Externally publishedYes

Keywords

  • Co-imaging
  • EPR
  • L-band
  • Resonator
  • Surface coil

ASJC Scopus subject areas

  • Nuclear and High Energy Physics
  • Biochemistry
  • Biophysics
  • Condensed Matter Physics

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  • Cite this

    Petryakov, S., Samouilov, A., Chzhan-Roytenberg, M., Kesselring, E., Sun, Z., & Zweier, J. L. (2009). Segmented surface coil resonator for in vivo EPR applications at 1.1 GHz. Journal of Magnetic Resonance, 198(1), 8-14. https://doi.org/10.1016/j.jmr.2008.12.014