Sedation depth during spinal anesthesia and survival in elderly patients undergoing hip fracture repair

Research output: Contribution to journalArticlepeer-review

Abstract

Low intraoperative Bispectral Index (BIS) values may be associated with increased mortality. In a previously reported trial to prevent delirium, we randomized patients undergoing hip fracture repair under spinal anesthesia to light (BIS >80) or deep (BIS approximately 50) sedation. We analyzed survival of patients in the original trial. Among all patients, mortality was equivalent across sedation groups. However, among patients with serious comorbidities (Charlson score >4), 1-year mortality was reduced in the light (22.2%) vs deep (43.6%) sedation group (hazard ratio [HR], 0.43; 95% confidence interval, 0.19-0.97; P = 0.04) during spinal anesthesia. Similarly, among patients with Charlson score >6, 1-year mortality was reduced in the light (28.6%) vs deep (52.6%) sedation group (HR 0.33; 95% confidence interval, 0.12-0.94; P = 0.04) during spinal anesthesia. Further research on reduced mortality after light sedation during spinal anesthesia is needed.

Original languageEnglish (US)
Pages (from-to)977-980
Number of pages4
JournalAnesthesia and analgesia
Volume118
Issue number5
DOIs
StatePublished - 2014

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine

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