Secretory antibody directed against rotavirus in human milk: measurement by means of enzyme linked immunosorbent assay

Robert H Yolken, R. G. Wyatt, L. Mata, J. J. Urrutia, B. Garciá, R. M. Chanock, A. Z. Kapikian

Research output: Contribution to journalArticle

Abstract

Human milk contains antibodies to a variety of enteropathic agents. We utilized the method of enzyme linked immunosorbent assay to investigate anti-rotavirus secretory IgA in 113 human milk and colostral specimens from a rural area in Guatemala, 32 colostral specimens from an urban area of Costa Rica, and 12 from an urban area of the United States. Anti-rotavirus SCIgA was found in all colostral samples and in 94% of the milk specimens. Both the absolute concentration of anti-rotavirus SCIgA and concentration relative to total SCIgA were highest in colostrum, falling to lower but detectable levels from one week to two years after birth. No significant differences were noted in the results from the specimens from three different geographic areas. The possible role of this antibody in immunity to rotavirus infection is discussed.

Original languageEnglish (US)
Pages (from-to)916-921
Number of pages6
JournalJournal of Pediatrics
Volume93
Issue number6
DOIs
StatePublished - 1978
Externally publishedYes

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Rotavirus
Human Milk
Enzyme-Linked Immunosorbent Assay
Antibodies
Guatemala
Rotavirus Infections
Costa Rica
Secretory Immunoglobulin A
Colostrum
Immunity
Milk
Parturition

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Secretory antibody directed against rotavirus in human milk : measurement by means of enzyme linked immunosorbent assay. / Yolken, Robert H; Wyatt, R. G.; Mata, L.; Urrutia, J. J.; Garciá, B.; Chanock, R. M.; Kapikian, A. Z.

In: Journal of Pediatrics, Vol. 93, No. 6, 1978, p. 916-921.

Research output: Contribution to journalArticle

Yolken, Robert H ; Wyatt, R. G. ; Mata, L. ; Urrutia, J. J. ; Garciá, B. ; Chanock, R. M. ; Kapikian, A. Z. / Secretory antibody directed against rotavirus in human milk : measurement by means of enzyme linked immunosorbent assay. In: Journal of Pediatrics. 1978 ; Vol. 93, No. 6. pp. 916-921.
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