Secondhand smoke is an important modifiable risk factor in sickle cell disease: A review of the current literature and areas for future research

S. Christy Sadreameli, Benjamin T. Kopp, Susan E. Creary, Michelle N. Eakin, Sharon McGrath-Morrow, John J. Strouse

Research output: Contribution to journalReview articlepeer-review

Abstract

Sickle cell disease (SCD) is an autosomal recessive hemoglobinopathy that causes significant morbidity and mortality related to chronic hemolytic anemia, vaso-occlusion, and resultant end-organ damage. Tobacco smoke exposure (TSE) through secondhand smoke exposure in people with SCD of all ages and through primary smoking in adolescents and adults is associated with significantly increased morbidity, with increased rates of emergency department visits and hospitalizations for painful vaso-occlusive crises and acute chest syndrome (ACS). Secondhand smoke is also associated with pulmonary function abnormalities in children with SCD who are already at risk for pulmonary function abnormalities on the basis of SCD. TSE is emerging as one of the few modifiable risk factors of SCD. This review discusses the current state of the evidence with respect to TSE and SCD morbidity, discusses potential mechanisms, and highlights current gaps in the evidence and future research directions.

Original languageEnglish (US)
Article number1131
JournalInternational journal of environmental research and public health
Volume13
Issue number11
DOIs
StatePublished - Nov 12 2016

Keywords

  • Environmental tobacco smoke
  • Pulmonary function tests
  • Secondhand smoke
  • Sickle cell disease
  • Tobacco

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Fingerprint

Dive into the research topics of 'Secondhand smoke is an important modifiable risk factor in sickle cell disease: A review of the current literature and areas for future research'. Together they form a unique fingerprint.

Cite this