Abstract
Background: In adults with chronic kidney disease (CKD), cigarette smoking is associated with an increased risk for CKD progression and transplant failure. In children, secondhand smoke (SHS) exposure has been associated with elevated blood pressure. There are no studies on the prevalence and effect of SHS exposure in CKD. Methods: Subjects were enrolled in the Chronic Kidney Disease in Children (CKiD) Study, an observational cohort of 366 children aged 1 to 16 years with CKD. Secondhand smoke exposure was obtained via questionnaire. SHS exposure was also determined based on urine cotinine (Ucot) measurements (1 ng/mL ≤ Ucot <75 ng/mL). The cross-sectional association of SHS exposure with proteinuria was assessed. Results: Using Ucot, 22 % of subjects were exposed to SHS. SHS exposure was significantly associated with lower maternal education and African American race, and a greater prevalence of nephrotic range proteinuria and left ventricular hypertrophy. In a multivariate model (including sex, age, race, maternal education, income level, private insurance status, abnormal birth history and CKD diagnosis), the prevalence odds of nephrotic range proteinuria was 2.64, (95 % confidence interval 1.08, 6.42) higher in children exposed to SHS compared to those unexposed. Conclusions: In our cohort of children with CKD, SHS exposure was common (22 %) and independently associated with nephrotic range proteinuria. Exposure to SHS may be an important factor to consider in CKD progression.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1243-1251 |
| Number of pages | 9 |
| Journal | Pediatric Nephrology |
| Volume | 28 |
| Issue number | 8 |
| DOIs | |
| State | Published - Aug 2013 |
Fingerprint
Keywords
- Chronic kidney disease progression
- Pediatric chronic kidney disease
- Proteinuria
- Secondhand smoke exposure
- Tobacco use
- Urine cotinine
ASJC Scopus subject areas
- Nephrology
- Pediatrics, Perinatology, and Child Health
Cite this
Secondhand smoke exposure is associated with proteinuria in children with chronic kidney disease. / Omoloja, Abiodun; Jerry-Fluker, Judith; Ng, Derek; Abraham, Alison Gump; Furth, Susan; Warady, Bradley A.; Mitsnefes, Mark.
In: Pediatric Nephrology, Vol. 28, No. 8, 08.2013, p. 1243-1251.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Secondhand smoke exposure is associated with proteinuria in children with chronic kidney disease
AU - Omoloja, Abiodun
AU - Jerry-Fluker, Judith
AU - Ng, Derek
AU - Abraham, Alison Gump
AU - Furth, Susan
AU - Warady, Bradley A.
AU - Mitsnefes, Mark
PY - 2013/8
Y1 - 2013/8
N2 - Background: In adults with chronic kidney disease (CKD), cigarette smoking is associated with an increased risk for CKD progression and transplant failure. In children, secondhand smoke (SHS) exposure has been associated with elevated blood pressure. There are no studies on the prevalence and effect of SHS exposure in CKD. Methods: Subjects were enrolled in the Chronic Kidney Disease in Children (CKiD) Study, an observational cohort of 366 children aged 1 to 16 years with CKD. Secondhand smoke exposure was obtained via questionnaire. SHS exposure was also determined based on urine cotinine (Ucot) measurements (1 ng/mL ≤ Ucot <75 ng/mL). The cross-sectional association of SHS exposure with proteinuria was assessed. Results: Using Ucot, 22 % of subjects were exposed to SHS. SHS exposure was significantly associated with lower maternal education and African American race, and a greater prevalence of nephrotic range proteinuria and left ventricular hypertrophy. In a multivariate model (including sex, age, race, maternal education, income level, private insurance status, abnormal birth history and CKD diagnosis), the prevalence odds of nephrotic range proteinuria was 2.64, (95 % confidence interval 1.08, 6.42) higher in children exposed to SHS compared to those unexposed. Conclusions: In our cohort of children with CKD, SHS exposure was common (22 %) and independently associated with nephrotic range proteinuria. Exposure to SHS may be an important factor to consider in CKD progression.
AB - Background: In adults with chronic kidney disease (CKD), cigarette smoking is associated with an increased risk for CKD progression and transplant failure. In children, secondhand smoke (SHS) exposure has been associated with elevated blood pressure. There are no studies on the prevalence and effect of SHS exposure in CKD. Methods: Subjects were enrolled in the Chronic Kidney Disease in Children (CKiD) Study, an observational cohort of 366 children aged 1 to 16 years with CKD. Secondhand smoke exposure was obtained via questionnaire. SHS exposure was also determined based on urine cotinine (Ucot) measurements (1 ng/mL ≤ Ucot <75 ng/mL). The cross-sectional association of SHS exposure with proteinuria was assessed. Results: Using Ucot, 22 % of subjects were exposed to SHS. SHS exposure was significantly associated with lower maternal education and African American race, and a greater prevalence of nephrotic range proteinuria and left ventricular hypertrophy. In a multivariate model (including sex, age, race, maternal education, income level, private insurance status, abnormal birth history and CKD diagnosis), the prevalence odds of nephrotic range proteinuria was 2.64, (95 % confidence interval 1.08, 6.42) higher in children exposed to SHS compared to those unexposed. Conclusions: In our cohort of children with CKD, SHS exposure was common (22 %) and independently associated with nephrotic range proteinuria. Exposure to SHS may be an important factor to consider in CKD progression.
KW - Chronic kidney disease progression
KW - Pediatric chronic kidney disease
KW - Proteinuria
KW - Secondhand smoke exposure
KW - Tobacco use
KW - Urine cotinine
UR - http://www.scopus.com/inward/record.url?scp=84879927342&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84879927342&partnerID=8YFLogxK
U2 - 10.1007/s00467-013-2456-1
DO - 10.1007/s00467-013-2456-1
M3 - Article
C2 - 23584848
AN - SCOPUS:84879927342
VL - 28
SP - 1243
EP - 1251
JO - Pediatric Nephrology
JF - Pediatric Nephrology
SN - 0931-041X
IS - 8
ER -