Secondhand smoke exposure and subclinical cardiovascular disease: The multi-ethnic study of atherosclerosis

Miranda Jones, Hoda S. Magid, Mahmoud Al-Rifai, John W. McEvoy, Joel D. Kaufman, Karen D. Hinckley Stukovsky, Moyses Szklo, Joseph Polak, Gregory L. Burke, Wendy S Post, Michael Blaha, Ana Navas Acien

Research output: Contribution to journalArticle

Abstract

Background--Few studies have evaluated the association between secondhand smoke (SHS) and subclinical cardiovascular disease among ethnically diverse populations. This study assesses the impact of SHS on inflammation and atherosclerosis (carotid intima-media thickness, coronary artery calcification, and peripheral arterial disease). Methods and Results--We examined 5032 nonsmoking adults aged 45 to 84 years without prior cardiovascular disease participating in the Multi-Ethnic Study of Atherosclerosis (MESA) from 2000 to 2002. SHS exposure was determined by self-report, and urinary cotinine was measured in a representative subset (n=2893). The multi-adjusted geometric mean ratios (95% CIs) for high-sensitivity C-reactive protein and interleukin-6 comparing 407 participants with SHS ≥12 h/wk versus 3035 unexposed participants were 1.13 (1.02-1.26) and 1.04 (0.98-1.11), respectively. The multi-adjusted geometric mean ratio for carotid intimamedia thickness was 1.02 (0.97-1.07). Fibrinogen and coronary artery calcification were not associated with SHS. The prevalence of peripheral arterial disease (ankle-brachial index ≤0.9 or ≥1.4) was associated with detectable urinary cotinine (odds ratio, 2.10; 95% CI, 1.09-4.04) but not with self-reported SHS. Urinary cotinine was not associated with inflammation or carotid intima-media thickness. Conclusions--Despite limited exposure assessment, this study supports the association of SHS exposure with inflammation and peripheral arterial disease.

Original languageEnglish (US)
Article numbere002965
JournalJournal of the American Heart Association
Volume5
Issue number12
DOIs
StatePublished - 2016

Fingerprint

Tobacco Smoke Pollution
Atherosclerosis
Cardiovascular Diseases
Cotinine
Peripheral Arterial Disease
Carotid Intima-Media Thickness
Inflammation
Coronary Vessels
Ankle Brachial Index
C-Reactive Protein
Fibrinogen
Self Report
Interleukin-6
Odds Ratio
Population

Keywords

  • Ankle-brachial index
  • Atherosclerosis
  • Carotid intima-media thickness
  • Coronary artery calcium
  • Inflammation
  • Peripheral artery disease
  • Secondhand smoke
  • Smoking

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Jones, M., Magid, H. S., Al-Rifai, M., McEvoy, J. W., Kaufman, J. D., Hinckley Stukovsky, K. D., ... Navas Acien, A. (2016). Secondhand smoke exposure and subclinical cardiovascular disease: The multi-ethnic study of atherosclerosis. Journal of the American Heart Association, 5(12), [e002965]. https://doi.org/10.1161/JAHA.115.002965

Secondhand smoke exposure and subclinical cardiovascular disease : The multi-ethnic study of atherosclerosis. / Jones, Miranda; Magid, Hoda S.; Al-Rifai, Mahmoud; McEvoy, John W.; Kaufman, Joel D.; Hinckley Stukovsky, Karen D.; Szklo, Moyses; Polak, Joseph; Burke, Gregory L.; Post, Wendy S; Blaha, Michael; Navas Acien, Ana.

In: Journal of the American Heart Association, Vol. 5, No. 12, e002965, 2016.

Research output: Contribution to journalArticle

Jones, Miranda ; Magid, Hoda S. ; Al-Rifai, Mahmoud ; McEvoy, John W. ; Kaufman, Joel D. ; Hinckley Stukovsky, Karen D. ; Szklo, Moyses ; Polak, Joseph ; Burke, Gregory L. ; Post, Wendy S ; Blaha, Michael ; Navas Acien, Ana. / Secondhand smoke exposure and subclinical cardiovascular disease : The multi-ethnic study of atherosclerosis. In: Journal of the American Heart Association. 2016 ; Vol. 5, No. 12.
@article{cba760ae8df242bba7e59bd5e327aa88,
title = "Secondhand smoke exposure and subclinical cardiovascular disease: The multi-ethnic study of atherosclerosis",
abstract = "Background--Few studies have evaluated the association between secondhand smoke (SHS) and subclinical cardiovascular disease among ethnically diverse populations. This study assesses the impact of SHS on inflammation and atherosclerosis (carotid intima-media thickness, coronary artery calcification, and peripheral arterial disease). Methods and Results--We examined 5032 nonsmoking adults aged 45 to 84 years without prior cardiovascular disease participating in the Multi-Ethnic Study of Atherosclerosis (MESA) from 2000 to 2002. SHS exposure was determined by self-report, and urinary cotinine was measured in a representative subset (n=2893). The multi-adjusted geometric mean ratios (95{\%} CIs) for high-sensitivity C-reactive protein and interleukin-6 comparing 407 participants with SHS ≥12 h/wk versus 3035 unexposed participants were 1.13 (1.02-1.26) and 1.04 (0.98-1.11), respectively. The multi-adjusted geometric mean ratio for carotid intimamedia thickness was 1.02 (0.97-1.07). Fibrinogen and coronary artery calcification were not associated with SHS. The prevalence of peripheral arterial disease (ankle-brachial index ≤0.9 or ≥1.4) was associated with detectable urinary cotinine (odds ratio, 2.10; 95{\%} CI, 1.09-4.04) but not with self-reported SHS. Urinary cotinine was not associated with inflammation or carotid intima-media thickness. Conclusions--Despite limited exposure assessment, this study supports the association of SHS exposure with inflammation and peripheral arterial disease.",
keywords = "Ankle-brachial index, Atherosclerosis, Carotid intima-media thickness, Coronary artery calcium, Inflammation, Peripheral artery disease, Secondhand smoke, Smoking",
author = "Miranda Jones and Magid, {Hoda S.} and Mahmoud Al-Rifai and McEvoy, {John W.} and Kaufman, {Joel D.} and {Hinckley Stukovsky}, {Karen D.} and Moyses Szklo and Joseph Polak and Burke, {Gregory L.} and Post, {Wendy S} and Michael Blaha and {Navas Acien}, Ana",
year = "2016",
doi = "10.1161/JAHA.115.002965",
language = "English (US)",
volume = "5",
journal = "Journal of the American Heart Association",
issn = "2047-9980",
publisher = "Wiley-Blackwell",
number = "12",

}

TY - JOUR

T1 - Secondhand smoke exposure and subclinical cardiovascular disease

T2 - The multi-ethnic study of atherosclerosis

AU - Jones, Miranda

AU - Magid, Hoda S.

AU - Al-Rifai, Mahmoud

AU - McEvoy, John W.

AU - Kaufman, Joel D.

AU - Hinckley Stukovsky, Karen D.

AU - Szklo, Moyses

AU - Polak, Joseph

AU - Burke, Gregory L.

AU - Post, Wendy S

AU - Blaha, Michael

AU - Navas Acien, Ana

PY - 2016

Y1 - 2016

N2 - Background--Few studies have evaluated the association between secondhand smoke (SHS) and subclinical cardiovascular disease among ethnically diverse populations. This study assesses the impact of SHS on inflammation and atherosclerosis (carotid intima-media thickness, coronary artery calcification, and peripheral arterial disease). Methods and Results--We examined 5032 nonsmoking adults aged 45 to 84 years without prior cardiovascular disease participating in the Multi-Ethnic Study of Atherosclerosis (MESA) from 2000 to 2002. SHS exposure was determined by self-report, and urinary cotinine was measured in a representative subset (n=2893). The multi-adjusted geometric mean ratios (95% CIs) for high-sensitivity C-reactive protein and interleukin-6 comparing 407 participants with SHS ≥12 h/wk versus 3035 unexposed participants were 1.13 (1.02-1.26) and 1.04 (0.98-1.11), respectively. The multi-adjusted geometric mean ratio for carotid intimamedia thickness was 1.02 (0.97-1.07). Fibrinogen and coronary artery calcification were not associated with SHS. The prevalence of peripheral arterial disease (ankle-brachial index ≤0.9 or ≥1.4) was associated with detectable urinary cotinine (odds ratio, 2.10; 95% CI, 1.09-4.04) but not with self-reported SHS. Urinary cotinine was not associated with inflammation or carotid intima-media thickness. Conclusions--Despite limited exposure assessment, this study supports the association of SHS exposure with inflammation and peripheral arterial disease.

AB - Background--Few studies have evaluated the association between secondhand smoke (SHS) and subclinical cardiovascular disease among ethnically diverse populations. This study assesses the impact of SHS on inflammation and atherosclerosis (carotid intima-media thickness, coronary artery calcification, and peripheral arterial disease). Methods and Results--We examined 5032 nonsmoking adults aged 45 to 84 years without prior cardiovascular disease participating in the Multi-Ethnic Study of Atherosclerosis (MESA) from 2000 to 2002. SHS exposure was determined by self-report, and urinary cotinine was measured in a representative subset (n=2893). The multi-adjusted geometric mean ratios (95% CIs) for high-sensitivity C-reactive protein and interleukin-6 comparing 407 participants with SHS ≥12 h/wk versus 3035 unexposed participants were 1.13 (1.02-1.26) and 1.04 (0.98-1.11), respectively. The multi-adjusted geometric mean ratio for carotid intimamedia thickness was 1.02 (0.97-1.07). Fibrinogen and coronary artery calcification were not associated with SHS. The prevalence of peripheral arterial disease (ankle-brachial index ≤0.9 or ≥1.4) was associated with detectable urinary cotinine (odds ratio, 2.10; 95% CI, 1.09-4.04) but not with self-reported SHS. Urinary cotinine was not associated with inflammation or carotid intima-media thickness. Conclusions--Despite limited exposure assessment, this study supports the association of SHS exposure with inflammation and peripheral arterial disease.

KW - Ankle-brachial index

KW - Atherosclerosis

KW - Carotid intima-media thickness

KW - Coronary artery calcium

KW - Inflammation

KW - Peripheral artery disease

KW - Secondhand smoke

KW - Smoking

UR - http://www.scopus.com/inward/record.url?scp=85006375482&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85006375482&partnerID=8YFLogxK

U2 - 10.1161/JAHA.115.002965

DO - 10.1161/JAHA.115.002965

M3 - Article

C2 - 27993830

AN - SCOPUS:85006375482

VL - 5

JO - Journal of the American Heart Association

JF - Journal of the American Heart Association

SN - 2047-9980

IS - 12

M1 - e002965

ER -