Secondary surgical cytoreduction for recurrent ovarian cancer

Robert L. Coleman, Nick M. Spirtos, Danielle Enserro, Thomas J. Herzog, Paul Sabbatini, Deborah K. Armstrong, Jae Weon Kim, Sang Yoon Park, Byoung Gie Kim, Joo Hyun Nam, Keiichi Fujiwara, Joan L. Walker, Ann C. Casey, Angeles Alvarez Secord, Steve Rubin, John K. Chan, Paul DiSilvestro, Susan A. Davidson, David E. Cohn, Krishnansu S. TewariKaren Basen-Engquist, Helen Q. Huang, Mark F. Brady, Robert S. Mannel

Research output: Contribution to journalArticle

Abstract

BACKGROUND Secondary surgical cytoreduction in women with platinum-sensitive, recurrent epithelial ovarian, primary peritoneal, or fallopian-Tube ("ovarian") cancer is widely practiced but has not been evaluated in phase 3 investigation. METHODS We randomly assigned patients with recurrent ovarian cancer who had received one previous therapy, had an interval during which no platinum-based chemotherapy was used (platinum-free interval) of 6 months or more, and had investigator-determined resectable disease (to no macroscopic residual disease) to undergo secondary surgical cytoreduction and then receive platinum-based chemotherapy or to receive platinumbased chemotherapy alone. Adjuvant chemotherapy (paclitaxel carboplatin or gemcitabine carboplatin) and use of bevacizumab were at the discretion of the investigator. The primary end point was overall survival. RESULTS A total of 485 patients underwent randomization, 240 to secondary cytoreduction before chemotherapy and 245 to chemotherapy alone. The median follow-up was 48.1 months. Complete gross resection was achieved in 67% of the patients assigned to surgery who underwent the procedure. Platinum-based chemotherapy with bevacizumab followed by bevacizumab maintenance was administered to 84% of the patients overall and was equally distributed between the two groups. The hazard ratio for death (surgery vs. no surgery) was 1.29 (95% confidence interval [CI], 0.97 to 1.72; P = 0.08), which corresponded to a median overall survival of 50.6 months and 64.7 months, respectively. Adjustment for platinum-free interval and chemotherapy choice did not alter the effect. The hazard ratio for disease progression or death (surgery vs. no surgery) was 0.82 (95% CI, 0.66 to 1.01; median progression-free survival, 18.9 months and 16.2 months, respectively). Surgical morbidity at 30 days was 9%; 1 patient (0.4%) died from postoperative complications. Patient-reported quality of life decreased significantly after surgery but did not differ significantly between the two groups after recovery. CONCLUSIONS In this trial involving patients with platinum-sensitive, recurrent ovarian cancer, secondary surgical cytoreduction followed by chemotherapy did not result in longer overall survival than chemotherapy alone. (Funded by the National Cancer Institute and others; GOG-0213 ClinicalTrials.gov number, NCT00565851.).

Original languageEnglish (US)
Pages (from-to)1929-1939
Number of pages11
JournalNew England Journal of Medicine
Volume381
Issue number20
DOIs
StatePublished - Nov 14 2019

ASJC Scopus subject areas

  • Medicine(all)

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    Coleman, R. L., Spirtos, N. M., Enserro, D., Herzog, T. J., Sabbatini, P., Armstrong, D. K., Weon Kim, J., Yoon Park, S., Gie Kim, B., Hyun Nam, J., Fujiwara, K., Walker, J. L., Casey, A. C., Secord, A. A., Rubin, S., Chan, J. K., DiSilvestro, P., Davidson, S. A., Cohn, D. E., ... Mannel, R. S. (2019). Secondary surgical cytoreduction for recurrent ovarian cancer. New England Journal of Medicine, 381(20), 1929-1939. https://doi.org/10.1056/NEJMoa1902626