Secondary screening of platinum compounds in human ovarian cancer xenografts in nude mice

E. Boven; M. M. Nauta; H. M M Schluper; F. Elferink; W. J F Van Der Vijgh; H. M. Pinedo

doi:10.1016/0277-5379(85)90023-9

Secondary screening of platinum compounds in human ovarian cancer xenografts in nude mice

E. Boven, M. M. Nauta, H. M M Schluper, F. Elferink, W. J F Van Der Vijgh, H. M. Pinedo

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Abstract

Five TNO platinum compounds were evaluated for antitumor activities in two human ovarian carcinoma tumor lines grown in nude mice. The most active drug, TNO-38, was investigated in five additional lines with a known range of sensitivity to cisplatin. None of the new compounds showed superior activity to cisplatin. The slightly lower activity of TNO-38 as compared to the parent compound was reproducible in all tumor lines. Besides the similarity in the antitumor activity, a remarkable correspondence in platinum distribution and retention at 24 hr of TNO-38 and cisplatin could be observed. Chromatographic analysis of the compounds in their injection fluids showed single peaks for TNO-26 and TNO-38. The degradation products of the latter drugs may have affected their activity and toxicity. These human ovarian cancer xenografts may offer a reliable screening model for selection of a cisplatin analog with a higher therapeutic index or without cross-resistance for treatment in ovarian cancer.

Original language	English (US)
Pages (from-to)	1253-1260
Number of pages	8
Journal	European Journal of Cancer and Clinical Oncology
Volume	21
Issue number	10
DOIs	https://doi.org/10.1016/0277-5379(85)90023-9
State	Published - 1985
Externally published	Yes

ASJC Scopus subject areas

Oncology

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title = "Secondary screening of platinum compounds in human ovarian cancer xenografts in nude mice",

abstract = "Five TNO platinum compounds were evaluated for antitumor activities in two human ovarian carcinoma tumor lines grown in nude mice. The most active drug, TNO-38, was investigated in five additional lines with a known range of sensitivity to cisplatin. None of the new compounds showed superior activity to cisplatin. The slightly lower activity of TNO-38 as compared to the parent compound was reproducible in all tumor lines. Besides the similarity in the antitumor activity, a remarkable correspondence in platinum distribution and retention at 24 hr of TNO-38 and cisplatin could be observed. Chromatographic analysis of the compounds in their injection fluids showed single peaks for TNO-26 and TNO-38. The degradation products of the latter drugs may have affected their activity and toxicity. These human ovarian cancer xenografts may offer a reliable screening model for selection of a cisplatin analog with a higher therapeutic index or without cross-resistance for treatment in ovarian cancer.",

author = "E. Boven and Nauta, {M. M.} and Schluper, {H. M M} and F. Elferink and {Van Der Vijgh}, {W. J F} and Pinedo, {H. M.}",

year = "1985",

doi = "10.1016/0277-5379(85)90023-9",

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T1 - Secondary screening of platinum compounds in human ovarian cancer xenografts in nude mice

AU - Boven, E.

AU - Nauta, M. M.

AU - Schluper, H. M M

AU - Elferink, F.

AU - Van Der Vijgh, W. J F

AU - Pinedo, H. M.

PY - 1985

Y1 - 1985

N2 - Five TNO platinum compounds were evaluated for antitumor activities in two human ovarian carcinoma tumor lines grown in nude mice. The most active drug, TNO-38, was investigated in five additional lines with a known range of sensitivity to cisplatin. None of the new compounds showed superior activity to cisplatin. The slightly lower activity of TNO-38 as compared to the parent compound was reproducible in all tumor lines. Besides the similarity in the antitumor activity, a remarkable correspondence in platinum distribution and retention at 24 hr of TNO-38 and cisplatin could be observed. Chromatographic analysis of the compounds in their injection fluids showed single peaks for TNO-26 and TNO-38. The degradation products of the latter drugs may have affected their activity and toxicity. These human ovarian cancer xenografts may offer a reliable screening model for selection of a cisplatin analog with a higher therapeutic index or without cross-resistance for treatment in ovarian cancer.

AB - Five TNO platinum compounds were evaluated for antitumor activities in two human ovarian carcinoma tumor lines grown in nude mice. The most active drug, TNO-38, was investigated in five additional lines with a known range of sensitivity to cisplatin. None of the new compounds showed superior activity to cisplatin. The slightly lower activity of TNO-38 as compared to the parent compound was reproducible in all tumor lines. Besides the similarity in the antitumor activity, a remarkable correspondence in platinum distribution and retention at 24 hr of TNO-38 and cisplatin could be observed. Chromatographic analysis of the compounds in their injection fluids showed single peaks for TNO-26 and TNO-38. The degradation products of the latter drugs may have affected their activity and toxicity. These human ovarian cancer xenografts may offer a reliable screening model for selection of a cisplatin analog with a higher therapeutic index or without cross-resistance for treatment in ovarian cancer.

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Secondary screening of platinum compounds in human ovarian cancer xenografts in nude mice

Abstract

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