Secondary mania in patients with HIV infection: Are antiretrovirals protective?

Anne M. Mijch, Fiona K. Judd, Constantine G. Lyketsos, Steve Ellen, Alex Cockram

Research output: Contribution to journalArticlepeer-review


A case-control study of 19 patients with HIV-associated mania and 57 HIV-seropositive control patients matched by CD4 cell count, age, and year of treatment was undertaken to investigate associations with risk factors for human immunodeficiency virus (HIV) infection, treatment, and disease. There was no significant difference between groups for HIV exposure category, baseline health status, or drugs other than antiretrovirals. Zidovudine therapy provided a significant protective effect against the development of mania, whether administered at or prior to diagnosis of mania. In a 3-year follow-up study, incident AIDS dementia was significantly more common in patients with mania, despite no apparent difference in survival between cases and controls. These findings strengthen the evidence of an etiological association of HIV neuropathology with AIDS mania by demonstrating a protective effect of an antiretroviral agent able to penetrate the central nervous system.

Original languageEnglish (US)
Pages (from-to)475-480
Number of pages6
JournalJournal of Neuropsychiatry and Clinical Neurosciences
Issue number4
StatePublished - Jan 1 1999
Externally publishedYes

ASJC Scopus subject areas

  • Clinical Neurology
  • Psychiatry and Mental health


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