Secondary causes of paroxysmal dyskinesia.

Jaishri Blakeley, Joseph Jankovic

Research output: Contribution to journalArticle

Abstract

PxD are sudden, episodic, involuntary movement disorders that may include any combination of dystonia, chorea, athetosis, or ballism. The majority of reported cases are familial or idiopathic; however, there have been several reports of secondary PxD. We report 20 new cases of secondary, non-psychogenic PxD, and review 130 cases reported in the literature. The results suggest that although PxD is a rare disorder, secondary forms may be more common than previously recognized, accounting for 26% of all cases in our series. Secondary cases are notable for their variability in age of onset, the presence of both kinesigenic and non-kinesigenic symptoms in some patients, the prevalence of sensory precipitants, and most importantly, the reversal of symptoms when the underlying etiology is treated in some patients. In addition to MS, other causes to be considered in patients presenting with PxD include cerebral vascular insufficiency and stroke, trauma, metabolic abnormalities, and CNS infections. Awareness of the association of these etiologies with secondary PxD will permit prompt diagnoses and appropriate interventions. Potential pathophysiologic mechanisms including loss of inhibition or primary neuronal hyperactivity are discussed. In addition, recent hypotheses regarding channelopathies in relation to PxD are presented.

Original languageEnglish (US)
Pages (from-to)401-420
Number of pages20
JournalAdvances in neurology
Volume89
StatePublished - 2002
Externally publishedYes

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Chorea
Athetosis
Channelopathies
Dystonia
Dyskinesias
Movement Disorders
Age of Onset
Blood Vessels
Stroke
Wounds and Injuries
Infection

Cite this

Secondary causes of paroxysmal dyskinesia. / Blakeley, Jaishri; Jankovic, Joseph.

In: Advances in neurology, Vol. 89, 2002, p. 401-420.

Research output: Contribution to journalArticle

Blakeley, Jaishri ; Jankovic, Joseph. / Secondary causes of paroxysmal dyskinesia. In: Advances in neurology. 2002 ; Vol. 89. pp. 401-420.
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