Second messenger systems and psychoactive drug action: Focus on the phosphoinositide system and lithium

Research output: Contribution to journalReview articlepeer-review

Abstract

Most models of psychotropic drug action have emphasized effects on the release or uptake of neurotransmitters as well as interactions with receptors. Stimulation of neurotransmitter receptors triggers a complex array of electrical and biochemical actions. Recent experimental advances have greatly clarified the second messenger systems underlying neurotransmitter actions, suggesting novel sites of action for psychotropic agents. The authors emphasize the phosphoinositide system and the implications of its involvement for the therapeutic actions of lithium.

Original languageEnglish (US)
Pages (from-to)1251-1260
Number of pages10
JournalAmerican Journal of Psychiatry
Volume146
Issue number10
DOIs
StatePublished - 1989

ASJC Scopus subject areas

  • Psychiatry and Mental health

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