TY - JOUR
T1 - Seasonal variation of disseminated Penicillium marneffei infections in northern Thailand
T2 - A clue to the reservoir?
AU - Chariyalertsak, Suwat
AU - Sirisanthana, Thira
AU - Supparatpinyo, Khuanchai
AU - Nelson, Kenrad E.
N1 - Funding Information:
Received 20 November 1995; revised 13 February 1996. Grant support: Fogarty International Center, National Institutes of Health, to Johns Hopkins University (5D43TWOOOIO). Informed consent was obtained from all patients, and the human experimentation guidelines of the US Department of Health and Human Services, Chiang Mai University, and Johns Hopkins University were followed. Reprints or correspondence: Dr. Kenrad E. Nelson, Dept. of Epidemiology, Johns Hopkins University, 624 N. Broadway St./Room 886, Baltimore, MD 21205.
PY - 1996
Y1 - 1996
N2 - Disseminated Penicillium marneffei infections are common AIDS-defining opportunistic infections among persons with human immunodeficiency virus (HIV) infection in northern Thailand. Penicilliosis due to P. marneffei is the third most frequent AIDS-defining infection in this population, after tuberculosis and cryptococcosis. Very little is known about the epidemiology and natural reservoir of P. marneffei. The seasonal distribution of two common AIDS-defining fungal infections was compared among patients diagnosed between 1991 and 1994 at Chiang Mai University Hospital. There were 550 cases (492 male, 58 female patients) of P. marneffei and 793 cases (685 male, 108 female patients) of Cryptococcus neoformans infection diagnosed. In each year, P. marneffei but not C. neoformans infections were more frequent in the rainy than the dry season. Seasonal variation of P. marneffei infectious in AIDS patients in northern Thailand may provide valuable information in determining the important reservoirs and exposures to this organism that lead to disseminated disease in these patients.
AB - Disseminated Penicillium marneffei infections are common AIDS-defining opportunistic infections among persons with human immunodeficiency virus (HIV) infection in northern Thailand. Penicilliosis due to P. marneffei is the third most frequent AIDS-defining infection in this population, after tuberculosis and cryptococcosis. Very little is known about the epidemiology and natural reservoir of P. marneffei. The seasonal distribution of two common AIDS-defining fungal infections was compared among patients diagnosed between 1991 and 1994 at Chiang Mai University Hospital. There were 550 cases (492 male, 58 female patients) of P. marneffei and 793 cases (685 male, 108 female patients) of Cryptococcus neoformans infection diagnosed. In each year, P. marneffei but not C. neoformans infections were more frequent in the rainy than the dry season. Seasonal variation of P. marneffei infectious in AIDS patients in northern Thailand may provide valuable information in determining the important reservoirs and exposures to this organism that lead to disseminated disease in these patients.
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U2 - 10.1093/infdis/173.6.1490
DO - 10.1093/infdis/173.6.1490
M3 - Article
C2 - 8648227
AN - SCOPUS:0029847066
SN - 0022-1899
VL - 173
SP - 1490
EP - 1493
JO - Journal of Infectious Diseases
JF - Journal of Infectious Diseases
IS - 6
ER -