Seasonal drivers of pneumococcal disease incidence: Impact of bacterial carriage and viral activity

Daniel M. Weinberger, Lindsay Renee Grant, Claudia Angelica Steiner, Robert C Weatherholtz, Mathuram Santosham, Cécile Viboud, Katherine L O'Brien

Research output: Contribution to journalArticle

Abstract

Background. Winter-seasonal epidemics of pneumococcal disease provide an opportunity to understand the drivers of incidence. We sought to determine whether seasonality of invasive pneumococcal disease is caused by increased nasopharyngeal transmission of the bacteria or increased susceptibility to invasive infections driven by cocirculating winter respiratory viruses.Methods. We analyzed pneumococcal carriage and invasive disease data collected from children

Original languageEnglish (US)
Pages (from-to)188-194
Number of pages7
JournalClinical Infectious Diseases
Volume58
Issue number2
DOIs
StatePublished - Jan 15 2014

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Incidence
Viruses
Bacteria
Infection

Keywords

  • Co-infections
  • Pneumococcal
  • Pneumonia
  • RSV
  • Seasonality

ASJC Scopus subject areas

  • Infectious Diseases
  • Microbiology (medical)

Cite this

Seasonal drivers of pneumococcal disease incidence : Impact of bacterial carriage and viral activity. / Weinberger, Daniel M.; Grant, Lindsay Renee; Steiner, Claudia Angelica; Weatherholtz, Robert C; Santosham, Mathuram; Viboud, Cécile; O'Brien, Katherine L.

In: Clinical Infectious Diseases, Vol. 58, No. 2, 15.01.2014, p. 188-194.

Research output: Contribution to journalArticle

Weinberger, Daniel M. ; Grant, Lindsay Renee ; Steiner, Claudia Angelica ; Weatherholtz, Robert C ; Santosham, Mathuram ; Viboud, Cécile ; O'Brien, Katherine L. / Seasonal drivers of pneumococcal disease incidence : Impact of bacterial carriage and viral activity. In: Clinical Infectious Diseases. 2014 ; Vol. 58, No. 2. pp. 188-194.
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